2-[5-(benzoyloxy)-4-(methoxycarbonyl)-6-methoxypyrimidin-2-yl]propan-2-amine hydrochloride

Base Information

Chemical Name:2-[5-(benzoyloxy)-4-(methoxycarbonyl)-6-methoxypyrimidin-2-yl]propan-2-amine hydrochloride
CAS No.:1370588-46-7
Molecular Formula:C₁₇H₁₉N₃O₅*ClH
Molecular Weight:381.816
Hs Code.:

Synonyms:2-[5-(benzoyloxy)-4-(methoxycarbonyl)-6-methoxypyrimidin-2-yl]propan-2-amine hydrochloride

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Chemical Property of 2-[5-(benzoyloxy)-4-(methoxycarbonyl)-6-methoxypyrimidin-2-yl]propan-2-amine hydrochloride

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Technology Process of 2-[5-(benzoyloxy)-4-(methoxycarbonyl)-6-methoxypyrimidin-2-yl]propan-2-amine hydrochloride

There total 3 articles about 2-[5-(benzoyloxy)-4-(methoxycarbonyl)-6-methoxypyrimidin-2-yl]propan-2-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 857664-99-4
methyl 5-(benzoyloxy)-2-(2-(benzyloxycarbonylamino)propan-2-yl)-6-methoxypyrimidine-4-carboxylate

: 1370588-46-7
2-[5-(benzoyloxy)-4-(methoxycarbonyl)-6-methoxypyrimidin-2-yl]propan-2-amine hydrochloride

Guidance literature:: With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol; water; for 3h; under 760.051 Torr;
DOI:10.1016/j.ejmech.2012.02.015

Reference yield:

: methyl 2-(2(((benzyloxy)carbonyl)amino)propan-2-yl)-5,6-dihydroxy-1,6-dihydropyrimidine-4-carboxylate

: 1370588-46-7
2-[5-(benzoyloxy)-4-(methoxycarbonyl)-6-methoxypyrimidin-2-yl]propan-2-amine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 10 h / 20 °C

2.1: lithium hydride / 1,4-dioxane / 1 h / 40 °C

2.2: 3 h / 60 °C

3.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; water / 3 h / 760.05 Torr

With pyridine; hydrogenchloride; palladium 10% on activated carbon; hydrogen; lithium hydride; In 1,4-dioxane; methanol; water;
DOI:10.1016/j.ejmech.2012.02.015

Reference yield:

: 518048-00-5
methyl 5-(benzoyloxy)-2-(2-(benzyloxycarbonylamino)propan-2-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxylate

: 1370588-46-7
2-[5-(benzoyloxy)-4-(methoxycarbonyl)-6-methoxypyrimidin-2-yl]propan-2-amine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydride / 1,4-dioxane / 1 h / 40 °C

1.2: 3 h / 60 °C

2.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; water / 3 h / 760.05 Torr

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; lithium hydride; In 1,4-dioxane; methanol; water;
DOI:10.1016/j.ejmech.2012.02.015