trans-(SC₄H₃/CO₂Me)-3-methoxycarbonyl-4-(p-tolyl)-4-(2'-thienyl)but-3-enoic acid

Base Information

• Chemical Name: trans-(SC₄H₃/CO₂Me)-3-methoxycarbonyl-4-(p-tolyl)-4-(2'-thienyl)but-3-enoic acid
• CAS No.: 81541-44-8
• Molecular Formula: C₁₇H₁₆O₄S
• Molecular Weight: 316.378

Synonyms:trans-(SC₄H₃/CO₂Me)-3-methoxycarbonyl-4-(p-tolyl)-4-(2'-thienyl)but-3-enoic acid

Chemical Property of trans-(SC₄H₃/CO₂Me)-3-methoxycarbonyl-4-(p-tolyl)-4-(2'-thienyl)but-3-enoic acid

Chemical Property:

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Technology Process of trans-(SC₄H₃/CO₂Me)-3-methoxycarbonyl-4-(p-tolyl)-4-(2'-thienyl)but-3-enoic acid

There total 1 articles about trans-(SC₄H₃/CO₂Me)-3-methoxycarbonyl-4-(p-tolyl)-4-(2'-thienyl)but-3-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-thienyl 4-methylphenyl ketone (6933-25-1) + Dimethyl succinate (106-65-0) → trans-(SC4H3/CO2Me)-3-methoxycarbonyl-4-(p-tolyl)-4-(2'-thienyl)but-3-enoic acid (81541-44-8)

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; for 1h;

DOI:10.1002/jhet.5570180805

Reference yield: 82.0%

acetic anhydride (108-24-7) + trans-(SC4H3/CO2Me)-3-methoxycarbonyl-4-(p-tolyl)-4-(2'-thienyl)but-3-enoic acid (81541-44-8) → methyl 7-(p-tolyl)-4-acetoxybenzothiophene-6-carboxylate (81557-47-3)

Guidance literature:

With sodium acetate; for 6h; Heating;

DOI:10.1002/jhet.5570180805

Reference yield: 42.0%

trans-(SC4H3/CO2Me)-3-methoxycarbonyl-4-(p-tolyl)-4-(2'-thienyl)but-3-enoic acid (81541-44-8) → 4-[1-Thiophen-2-yl-1-p-tolyl-meth-(E)-ylidene]-tetrahydro-pyridazine-3,6-dione (81541-45-9)

Guidance literature:

With hydrazine hydrate; In ethanol; 1.)heating, 30 min 2.)overnight;

DOI:10.1002/jhet.5570180805

upstream raw materials:

2-thienyl 4-methylphenyl ketone

Dimethyl succinate

Downstream raw materials:

methyl 7-(p-tolyl)-4-acetoxybenzothiophene-6-carboxylate

2-thienyl 4-methylphenyl ketone

4-[1-Thiophen-2-yl-1-p-tolyl-meth-(E)-ylidene]-tetrahydro-pyridazine-3,6-dione

(E)-2-Chlorocarbonylmethyl-3-thiophen-2-yl-3-p-tolyl-acrylic acid methyl ester

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