5-benzyloxy-3-(tert-butyloxycarbonyl)-1-(hydroxymethyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinoline

Base Information

• Chemical Name: 5-benzyloxy-3-(tert-butyloxycarbonyl)-1-(hydroxymethyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinoline
• CAS No.: 444565-02-0
• Molecular Formula: C₂₄H₂₆N₂O₄
• Molecular Weight: 406.481

Synonyms:5-benzyloxy-3-(tert-butyloxycarbonyl)-1-(hydroxymethyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinoline

Chemical Property of 5-benzyloxy-3-(tert-butyloxycarbonyl)-1-(hydroxymethyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinoline

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Technology Process of 5-benzyloxy-3-(tert-butyloxycarbonyl)-1-(hydroxymethyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinoline

There total 1 articles about 5-benzyloxy-3-(tert-butyloxycarbonyl)-1-(hydroxymethyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-(acetoxymethyl)-5-benzyloxy-3-(tert-butyloxycarbonyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinoline → 5-benzyloxy-3-(tert-butyloxycarbonyl)-1-(hydroxymethyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinoline (444565-02-0)

Guidance literature:

With water; caesium carbonate; In ethanol; for 0.5h; Reflux;

DOI:10.1021/jm9008746

Reference yield: 100.0%

5-benzyloxy-3-(tert-butyloxycarbonyl)-1-(hydroxymethyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinoline (444565-02-0) → 5-benzyloxy-3-(tert-butyloxycarbonyl)-1-(chloromethyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinoline (444565-04-2)

Guidance literature:

With tetrachloromethane; triphenylphosphine; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1021/jm9008746

Reference yield: 86.0%

5-benzyloxy-3-(tert-butyloxycarbonyl)-1-(hydroxymethyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinoline (444565-02-0) + methanesulfonyl chloride (124-63-0) → 5-benzyloxy-1-(methylsulfonyloxymethyl)-3-(tert-butyloxycarbonyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinoline (444565-03-1)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1021/jm9008746

Downstream raw materials:

5-benzyloxy-3-(tert-butyloxycarbonyl)-1-(chloromethyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinoline

5-benzyloxy-1-(methylsulfonyloxymethyl)-3-(tert-butyloxycarbonyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinoline

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