1-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-(6-methoxypyridin-3-ylamino)pyridin-3-yl)methyl)piperidin-4-ol

Base Information

Chemical Name:1-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-(6-methoxypyridin-3-ylamino)pyridin-3-yl)methyl)piperidin-4-ol
CAS No.:1253574-96-7
Molecular Formula:C₃₇H₄₂N₈O₄
Molecular Weight:662.792
Hs Code.:

Synonyms:1-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-(6-methoxypyridin-3-ylamino)pyridin-3-yl)methyl)piperidin-4-ol

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Chemical Property of 1-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-(6-methoxypyridin-3-ylamino)pyridin-3-yl)methyl)piperidin-4-ol

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Technology Process of 1-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-(6-methoxypyridin-3-ylamino)pyridin-3-yl)methyl)piperidin-4-ol

There total 4 articles about 1-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-(6-methoxypyridin-3-ylamino)pyridin-3-yl)methyl)piperidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 5382-16-1
4-HYDROXYPIPERIDINE

: 1253574-95-6
(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-(6-methoxypyridin-3-ylamino)pyridin-3-yl)methyl methanesulfonate

: 1253574-96-7
1-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-(6-methoxypyridin-3-ylamino)pyridin-3-yl)methyl)piperidin-4-ol

Guidance literature:: With triethylamine; In dichloromethane; for 16h; Inert atmosphere;
DOI:10.1021/jm300184s

Reference yield:

: 1253571-12-8
4-(5-(1,3-dioxolan-2-yl)-2-fluoropyridin-3-yl)-N,N-bis-(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

: 1253574-96-7
1-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-(6-methoxypyridin-3-ylamino)pyridin-3-yl)methyl)piperidin-4-ol

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

2: sodium tetrahydroborate / methanol / 0.83 h / 0 - 22 °C / Inert atmosphere

3: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

4: triethylamine / dichloromethane / 16 h / Inert atmosphere

With sodium tetrahydroborate; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm300184s

Reference yield:

: 1253571-18-4
5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-(6-methoxypyridin-3-ylamino)nicotinaldehyde

: 1253574-96-7
1-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-(6-methoxypyridin-3-ylamino)pyridin-3-yl)methyl)piperidin-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / methanol / 0.83 h / 0 - 22 °C / Inert atmosphere

2: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3: triethylamine / dichloromethane / 16 h / Inert atmosphere

With sodium tetrahydroborate; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm300184s