ethyl 2-((4-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)amino)-4,5-dihydro-1H-imidazole-1-carboxylate

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Chemical Name:ethyl 2-((4-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)amino)-4,5-dihydro-1H-imidazole-1-carboxylate
CAS No.:1421359-59-2
Molecular Formula:C₂₀H₂₁N₅O₄S
Molecular Weight:427.484
Hs Code.:

Synonyms:ethyl 2-((4-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)amino)-4,5-dihydro-1H-imidazole-1-carboxylate

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Chemical Property of ethyl 2-((4-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)amino)-4,5-dihydro-1H-imidazole-1-carboxylate

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Technology Process of ethyl 2-((4-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)amino)-4,5-dihydro-1H-imidazole-1-carboxylate

There total 3 articles about ethyl 2-((4-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)amino)-4,5-dihydro-1H-imidazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1287747-68-5
4-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-amine

: 86366-45-2
2-(ethylthio)-4,5-dihydro-1H-imidazole-1-carboxylic acid ethyl ester

: 1421359-59-2
ethyl 2-((4-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)amino)-4,5-dihydro-1H-imidazole-1-carboxylate

Guidance literature:: 4-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-amine; 2-(ethylthio)-4,5-dihydro-1H-imidazole-1-carboxylic acid ethyl ester; With acetic acid; at 90 ℃;

With sodium carbonate; In water;

Reference yield:

: 1227270-73-6
4-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

: 1421359-59-2
ethyl 2-((4-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)amino)-4,5-dihydro-1H-imidazole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutylammonium nitrate; trifluoroacetic anhydride / dichloromethane / 1.5 h / 0 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 16 h / 20 °C / Inert atmosphere

3: acetic acid / 90 °C

With palladium 10% on activated carbon; hydrogen; tetrabutylammonium nitrate; acetic acid; trifluoroacetic anhydride; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 889939-25-7
1-(benzenesulfonyl)-4-bromo-1H-pyrrolo[2,3-b]pyridine

: 1421359-59-2
ethyl 2-((4-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)amino)-4,5-dihydro-1H-imidazole-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide; bis-triphenylphosphine-palladium(II) chloride / 20 - 150 °C / Inert atmosphere

2: tetrabutylammonium nitrate; trifluoroacetic anhydride / dichloromethane / 1.5 h / 0 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 16 h / 20 °C / Inert atmosphere

4: acetic acid / 90 °C

With bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; hydrogen; tetrabutylammonium nitrate; acetic acid; N,N-dimethyl-formamide; trifluoroacetic anhydride; In tetrahydrofuran; ethanol; dichloromethane;