4- Methyl-1 -(phenylsulfonyl)-1 H-pyrrolo[2,3-b]pyridine

Base Information

Chemical Name:4- Methyl-1 -(phenylsulfonyl)-1 H-pyrrolo[2,3-b]pyridine
CAS No.:1227270-73-6
Molecular Formula:C14H12N2O2S
Molecular Weight:272.327
Hs Code.:2933990090
Mol file:1227270-73-6.mol

Synonyms:4- Methyl-1 -(phenylsulfonyl)-1 H-pyrrolo[2,3-b]pyridine;1-(Phenylsulphonyl)-4-Methyl-7-azaindole;1-(phenylsulfonyl)-4-methyl-7-azaindole

Suppliers and Price of 4- Methyl-1 -(phenylsulfonyl)-1 H-pyrrolo[2,3-b]pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine
2mg
$ 60.00

Crysdot
4-Methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine 95+%
1g
$ 770.00

Chemenu
1-(Phenylsulphonyl)-4-methyl-7-azaindole 95%
1g
$ 720.00

Alichem
4-Methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine
1g
$ 841.50

Total 10 raw suppliers

Chemical Property of 4- Methyl-1 -(phenylsulfonyl)-1 H-pyrrolo[2,3-b]pyridine

Chemical Property:

PSA：60.34000
LogP:3.66250
Storage Temp.:2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4- Methyl-1 -(phenylsulfonyl)-1 H-pyrrolo[2,3-b]pyridine

There total 3 articles about 4- Methyl-1 -(phenylsulfonyl)-1 H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 889939-25-7
1-(benzenesulfonyl)-4-bromo-1H-pyrrolo[2,3-b]pyridine

: 594-27-4
tetramethylstannane

: 1227270-73-6
4-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; N,N-dimethyl-formamide; at 20 - 150 ℃; Inert atmosphere;

Reference yield: 65.0%

: 824-24-8
4-methyl-1H-pyrrolo[2,3-b]pyridine

: 98-09-9
benzenesulfonyl chloride

: 1227270-73-6
4-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: 4-methyl-1H-pyrrolo[2,3-b]pyridine; With tetrabutylammomium bromide; potassium hydroxide; In dichloromethane; water; at 28 ℃; for 0.166667h;

benzenesulfonyl chloride; In dichloromethane; water; at 30 ℃; for 4h;
DOI:10.1021/acs.jmedchem.8b00392

Reference yield:

: 55052-28-3
4-chloro-7-azaindole

: 1227270-73-6
4-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / diethyl ether; toluene / 3 h / 30 - 80 °C / Inert atmosphere

2.1: potassium hydroxide; tetrabutylammomium bromide / dichloromethane; water / 0.17 h / 28 °C

2.2: 4 h / 30 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrabutylammomium bromide; potassium hydroxide; In diethyl ether; dichloromethane; water; toluene; 1.1: |Kumada Cross-Coupling;
DOI:10.1021/acs.jmedchem.8b00392