Benzoic acid 4-[1-(benzyl-{2-[2-(2-hydroxy-1-methoxycarbonyl-ethyl)-1H-indol-3-yl]-ethyl}-amino)-meth-(E)-ylidene]-5-oxo-hexyl ester

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Chemical Name:Benzoic acid 4-[1-(benzyl-{2-[2-(2-hydroxy-1-methoxycarbonyl-ethyl)-1H-indol-3-yl]-ethyl}-amino)-meth-(E)-ylidene]-5-oxo-hexyl ester
CAS No.:607354-00-7
Molecular Formula:C₃₅H₃₈N₂O₆
Molecular Weight:582.697
Hs Code.:

Synonyms:Benzoic acid 4-[1-(benzyl-{2-[2-(2-hydroxy-1-methoxycarbonyl-ethyl)-1H-indol-3-yl]-ethyl}-amino)-meth-(E)-ylidene]-5-oxo-hexyl ester

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Chemical Property of Benzoic acid 4-[1-(benzyl-{2-[2-(2-hydroxy-1-methoxycarbonyl-ethyl)-1H-indol-3-yl]-ethyl}-amino)-meth-(E)-ylidene]-5-oxo-hexyl ester

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Technology Process of Benzoic acid 4-[1-(benzyl-{2-[2-(2-hydroxy-1-methoxycarbonyl-ethyl)-1H-indol-3-yl]-ethyl}-amino)-meth-(E)-ylidene]-5-oxo-hexyl ester

There total 5 articles about Benzoic acid 4-[1-(benzyl-{2-[2-(2-hydroxy-1-methoxycarbonyl-ethyl)-1H-indol-3-yl]-ethyl}-amino)-meth-(E)-ylidene]-5-oxo-hexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 146681-75-6
2-[3-(2-Benzylamino-ethyl)-1H-indol-2-yl]-3-hydroxy-propionic acid methyl ester

: 607353-98-0
benzoic acid (4-bromomethylene-5-oxo)hexyl ester

: 607354-00-7
Benzoic acid 4-[1-(benzyl-{2-[2-(2-hydroxy-1-methoxycarbonyl-ethyl)-1H-indol-3-yl]-ethyl}-amino)-meth-(E)-ylidene]-5-oxo-hexyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In methanol; at 20 ℃; for 48h;
DOI:10.1016/S0040-4020(03)00902-5

Reference yield:

: 245758-34-3
benzoic acid (3-iodopropyl) ester

: 607354-00-7
Benzoic acid 4-[1-(benzyl-{2-[2-(2-hydroxy-1-methoxycarbonyl-ethyl)-1H-indol-3-yl]-ethyl}-amino)-meth-(E)-ylidene]-5-oxo-hexyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / potassium carbonate / acetone / 48 h / Heating

2: 43 percent / potassium carbonate / H₂O / 12 h / 20 °C

3: 92 percent / bromine / CH₂Cl₂ / 1 h / 20 °C

4: 63 percent / tetrabutylammonium fluoride monohydrate / hexamethylphosphoric acid triamide / 12 h / 20 °C

5: 30 percent / N,N-diisopropylethylamine / methanol / 48 h / 20 °C

With tetrabutyl ammonium fluoride; bromine; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; water; acetone;
DOI:10.1016/S0040-4020(03)00902-5

Reference yield:

: 607353-94-6
benzoic acid (4-methylene-5-oxo)hexyl ester

: 607354-00-7
Benzoic acid 4-[1-(benzyl-{2-[2-(2-hydroxy-1-methoxycarbonyl-ethyl)-1H-indol-3-yl]-ethyl}-amino)-meth-(E)-ylidene]-5-oxo-hexyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / bromine / CH₂Cl₂ / 1 h / 20 °C

2: 63 percent / tetrabutylammonium fluoride monohydrate / hexamethylphosphoric acid triamide / 12 h / 20 °C

3: 30 percent / N,N-diisopropylethylamine / methanol / 48 h / 20 °C

With tetrabutyl ammonium fluoride; bromine; N-ethyl-N,N-diisopropylamine; In methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1016/S0040-4020(03)00902-5