Technology Process of 5-[3-(4-methoxybenzyloxy)-propyl]-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid
There total 5 articles about 5-[3-(4-methoxybenzyloxy)-propyl]-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
In
dichloromethane;
at 20 ℃;
DOI:10.1021/jo050193e
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 90 percent / sodium hydride; tetra(n-butyl)ammonium iodide / dimethylformamide / 1 h / 0 °C
2: 95 percent / oxalyl chloride; DMSO; triethylamine / CH2Cl2 / -78 - 20 °C
3: 89 percent / benzene / 6 h / Heating
4: 96 percent / potassium ferricyanide; potassium carbonate; osmium tetroxide / (DHQD)2PHAL; methanesulfonamide / 2-methyl-propan-2-ol; H2O; toluene / 24 h / 0 °C
5: 95 percent / p-TSA / CH2Cl2 / 20 °C
With
osmium(VIII) oxide; oxalyl dichloride; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; potassium hexacyanoferrate(III);
methanesulfonamide; 1,4-bis(9-O-dihydroquinidine)phthalazine;
In
dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; benzene;
2: Swern oxidation / 3: Wittig olefination / 4: Sharpless asymmetric dihydroxylation;
DOI:10.1021/jo050193e
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 95 percent / oxalyl chloride; DMSO; triethylamine / CH2Cl2 / -78 - 20 °C
2: 89 percent / benzene / 6 h / Heating
3: 96 percent / potassium ferricyanide; potassium carbonate; osmium tetroxide / (DHQD)2PHAL; methanesulfonamide / 2-methyl-propan-2-ol; H2O; toluene / 24 h / 0 °C
4: 95 percent / p-TSA / CH2Cl2 / 20 °C
With
osmium(VIII) oxide; oxalyl dichloride; potassium carbonate; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; potassium hexacyanoferrate(III);
methanesulfonamide; 1,4-bis(9-O-dihydroquinidine)phthalazine;
In
dichloromethane; water; toluene; tert-butyl alcohol; benzene;
1: Swern oxidation / 2: Wittig olefination / 3: Sharpless asymmetric dihydroxylation;
DOI:10.1021/jo050193e
