(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-3-(5-phenyl-1H-imidazol-2-yl)-2,3-dihydro-5(1H)-indolizinone

Base Information

Chemical Name:(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-3-(5-phenyl-1H-imidazol-2-yl)-2,3-dihydro-5(1H)-indolizinone
CAS No.:1445863-47-7
Molecular Formula:C₂₄H₁₈ClN₇O
Molecular Weight:455.906
Hs Code.:

Synonyms:(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-3-(5-phenyl-1H-imidazol-2-yl)-2,3-dihydro-5(1H)-indolizinone

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Chemical Property of (3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-3-(5-phenyl-1H-imidazol-2-yl)-2,3-dihydro-5(1H)-indolizinone

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Technology Process of (3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-3-(5-phenyl-1H-imidazol-2-yl)-2,3-dihydro-5(1H)-indolizinone

There total 11 articles about (3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-3-(5-phenyl-1H-imidazol-2-yl)-2,3-dihydro-5(1H)-indolizinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1445865-87-1
2-oxo-2-phenylethyl (3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo-1,2,3,5-tetrahydro-3-indolizinecarboxylate

: 1445863-47-7
(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-3-(5-phenyl-1H-imidazol-2-yl)-2,3-dihydro-5(1H)-indolizinone

Guidance literature:: With ammonium acetate; acetic acid; In toluene; for 2h; Reflux;

Reference yield:

: 7149-65-7
ethyl (S)-pyroglutamate

: 1445863-47-7
(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-3-(5-phenyl-1H-imidazol-2-yl)-2,3-dihydro-5(1H)-indolizinone

Guidance literature:: Multi-step reaction with 11 steps

1.1: dichloromethane / 3 h / 20 °C

2.1: triethylamine / 3 h / 120 °C

3.1: sodium hydroxide / 20 °C

4.1: hydrogenchloride; water / 20 h / 140 °C

5.1: sulfuric acid / 4 h / 100 °C

6.1: triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

7.1: cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 105 °C / Inert atmosphere

8.1: sodium hydroxide; methanol / 4 h / 20 °C

9.1: acetic acid / 0.5 h

9.2: 20 °C

10.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

10.2: 2 h / 20 °C

11.1: acetic acid; ammonium acetate / toluene / 2 h / Reflux

With hydrogenchloride; methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; ammonium acetate; water; potassium carbonate; acetic acid; triethylamine; cesium fluoride; sodium hydroxide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1445865-59-7
(3S)-7-(2-amino-5-chlorophenyl)-5-oxo-1,2,3,5-tetrahydroindolizine-3-carboxylic acid

: 1445863-47-7
(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-3-(5-phenyl-1H-imidazol-2-yl)-2,3-dihydro-5(1H)-indolizinone

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / 0.5 h

1.2: 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 2 h / 20 °C

3.1: acetic acid; ammonium acetate / toluene / 2 h / Reflux

With ammonium acetate; potassium carbonate; acetic acid; In N,N-dimethyl-formamide; toluene;