2-oxo-2-phenylethyl (3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo-1,2,3,5-tetrahydro-3-indolizinecarboxylate

Base Information

Chemical Name:2-oxo-2-phenylethyl (3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo-1,2,3,5-tetrahydro-3-indolizinecarboxylate
CAS No.:1445865-87-1
Molecular Formula:C₂₄H₁₈ClN₅O₄
Molecular Weight:475.891
Hs Code.:

Synonyms:2-oxo-2-phenylethyl (3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo-1,2,3,5-tetrahydro-3-indolizinecarboxylate

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Chemical Property of 2-oxo-2-phenylethyl (3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo-1,2,3,5-tetrahydro-3-indolizinecarboxylate

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Technology Process of 2-oxo-2-phenylethyl (3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo-1,2,3,5-tetrahydro-3-indolizinecarboxylate

There total 9 articles about 2-oxo-2-phenylethyl (3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo-1,2,3,5-tetrahydro-3-indolizinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1445865-60-0
(3S)-7-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-5-oxo-1,2,3,5-tetrahydroindolizine-3-carboxylic acid

: 70-11-1
α-bromoacetophenone

: 1445865-87-1
2-oxo-2-phenylethyl (3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo-1,2,3,5-tetrahydro-3-indolizinecarboxylate

Guidance literature:: (3S)-7-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-5-oxo-1,2,3,5-tetrahydroindolizine-3-carboxylic acid; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

α-bromoacetophenone; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 7149-65-7
ethyl (S)-pyroglutamate

: 1445865-87-1
2-oxo-2-phenylethyl (3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo-1,2,3,5-tetrahydro-3-indolizinecarboxylate

Guidance literature:: Multi-step reaction with 10 steps

1.1: dichloromethane / 3 h / 20 °C

2.1: triethylamine / 3 h / 120 °C

3.1: sodium hydroxide / 20 °C

4.1: hydrogenchloride; water / 20 h / 140 °C

5.1: sulfuric acid / 4 h / 100 °C

6.1: triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

7.1: cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 105 °C / Inert atmosphere

8.1: sodium hydroxide; methanol / 4 h / 20 °C

9.1: acetic acid / 0.5 h

9.2: 20 °C

10.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

10.2: 2 h / 20 °C

With hydrogenchloride; methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; water; potassium carbonate; acetic acid; triethylamine; cesium fluoride; sodium hydroxide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1097302-48-1
ethyl (2S)-5-methoxy-3,4-dihydro-2H-pyrrole-2-carboxylate

: 1445865-87-1
2-oxo-2-phenylethyl (3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo-1,2,3,5-tetrahydro-3-indolizinecarboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine / 3 h / 120 °C

2.1: sodium hydroxide / 20 °C

3.1: hydrogenchloride; water / 20 h / 140 °C

4.1: sulfuric acid / 4 h / 100 °C

5.1: triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

6.1: cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 105 °C / Inert atmosphere

7.1: sodium hydroxide; methanol / 4 h / 20 °C

8.1: acetic acid / 0.5 h

8.2: 20 °C

9.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

9.2: 2 h / 20 °C

With hydrogenchloride; methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; water; potassium carbonate; acetic acid; triethylamine; cesium fluoride; sodium hydroxide; In 1,4-dioxane; N,N-dimethyl-formamide;