4-(p-Cyclopropylphenyl)-3-carbethoxy-2-aminothiophene

Base Information

Chemical Name:4-(p-Cyclopropylphenyl)-3-carbethoxy-2-aminothiophene
CAS No.:120109-76-4
Molecular Formula:C₁₆H₁₇NO₂S
Molecular Weight:287.382
Hs Code.:
DSSTox Substance ID:DTXSID601184916

Synonyms:120109-76-4;Ethyl 2-amino-4-(4-cyclopropylphenyl)-3-thiophenecarboxylate;Oprea1_051434;4-(p-cyclopropylphenyl)-3-carbethoxy-2-aminothiophene;DTXSID601184916;ethyl 2-amino-4-(4-cyclopropylphenyl)thiophene-3-carboxylate

Suppliers and Price of 4-(p-Cyclopropylphenyl)-3-carbethoxy-2-aminothiophene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(p-Cyclopropylphenyl)-3-carbethoxy-2-aminothiophene

Chemical Property:

XLogP3:4.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:287.09799996
Heavy Atom Count:20
Complexity:350

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1=C(SC=C1C2=CC=C(C=C2)C3CC3)N

Technology Process of 4-(p-Cyclopropylphenyl)-3-carbethoxy-2-aminothiophene

There total 4 articles about 4-(p-Cyclopropylphenyl)-3-carbethoxy-2-aminothiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 120109-73-1
(Z)-2-Cyano-3-(4-cyclopropyl-phenyl)-but-2-enoic acid ethyl ester

: 120109-76-4
4-(p-cyclopropylphenyl)-3-ethoxycarbonyl-2-aminothiophene

Guidance literature:: With sulfur; diethylamine; In ethanol; at 70 - 75 ℃;
DOI:10.1007/BF00479336

Reference yield: 52.0%

: 120109-73-1
2-cyano-3-(p-cyclopropylphenyl)-but-2-enoic acid ethyl ester

: 120109-76-4
4-(p-cyclopropylphenyl)-3-ethoxycarbonyl-2-aminothiophene

Guidance literature:: With sulfur; diethylamine; In ethanol; at 50 - 60 ℃;
DOI:10.1007/BF00764665

Reference yield:

: 6921-45-5
1-(4-cyclopropylphenyl)ethanone

: 120109-76-4
4-(p-cyclopropylphenyl)-3-ethoxycarbonyl-2-aminothiophene

Guidance literature:: Multi-step reaction with 2 steps

1: 35 percent

2: 52 percent / sulfur, diethylamine, / ethanol / 70 - 75 °C

With sulfur; diethylamine; In ethanol;
DOI:10.1007/BF00479336