6921-45-5

Usage

Uses

Used in Biochemical Research:
Ethanone, 1-(4-cyclopropylphenyl)(9CI) is employed as a reagent in biochemical research for its ability to participate in a variety of chemical reactions and preparations. Its unique structure allows it to be a versatile component in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Ethanone, 1-(4-cyclopropylphenyl)(9CI) is used as an intermediate in the synthesis of various pharmaceutical compounds. Its chemical properties make it a valuable building block for the development of new drugs and medicinal agents.
Used in Chemical Synthesis:
Ethanone, 1-(4-cyclopropylphenyl)(9CI) is utilized as a key component in chemical synthesis processes, where its reactivity and stability contribute to the formation of desired products. Its presence in the Ninth Collective Index highlights its significance in the field of chemistry.
Used in Material Science:
In material science, Ethanone, 1-(4-cyclopropylphenyl)(9CI) may be used to develop new materials with specific properties, such as improved stability or reactivity, by incorporating its unique molecular structure into the material's composition.

InChI:InChI=1/C11H12O/c1-8(12)9-2-4-10(5-3-9)11-6-7-11/h2-5,11H,6-7H2,1H3

Upstream product

• 4333-56-6 cyclopropyl bromide 
• 109613-00-5 4-acetophenyl triflate 
• 925430-09-7 tricyclopropylbismuthane 
• 13329-40-3 4-Iodoacetophenone 
• 1144509-67-0 2-(4-cyclopropylphenyl)-2-propoxyl 
• 19936-09-5 2-(4-cyclopropylphenyl)-2-propanol 
• 99-90-1 para-bromoacetophenone 
• 99-91-2 para-chloroacetophenone 
• 201230-82-2 carbon monoxide 
• 10537-63-0 1-(4-vinylphenyl)ethanone 
• 75-11-6 diiodomethane 
• 411235-57-9 cyclopropylboronic acid 
• 23719-81-5 tri(cyclopropyl)indium 
• 75-36-5 acetyl chloride 

Downstream Products

• 1798-82-9 4-cyclopropylbenzoic acid 
• 19936-10-8 p-cyclopropyl-α-methylstyrene 
• 40641-97-2 α-(p-Cyclopropylphenyl)aethanol 
• 19936-11-9 N-(4-cyclopropylphenyl)acetamide 
• 80857-71-2 1-(4-cinnamoylphenyl)cyclopropane 
• 120109-73-1 (Z)-2-Cyano-3-(4-cyclopropyl-phenyl)-but-2-enoic acid ethyl ester 
• 73005-35-3 (2,4-dinitrophenyl)hydrazone of p-cyclopropylacetophenone 
• 35076-76-7 4-ethyl-1-cyclopropylbenzene 
• 39773-69-8 2-Nitro-4-acetylphenylcyclopropane 
• 19824-39-6 p-Cyclopropyl-styrol 
• 1170061-64-9 C₁₅H₁₆O₄ 

Relevant academic research and scientific papers

CARBAMATE DERIVATIVES AND USES THEREOF

The present disclosure relates to compounds of Formula (I): and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.

Redox-Neutral Photocatalytic Cyclopropanation via Radical/Polar Crossover

A benchtop stable, bifunctional reagent for the redox-neutral cyclopropanation of olefins has been developed. Triethylammonium bis(catecholato)iodomethylsilicate can be readily prepared on multigram scale. Using this reagent in combination with an organic photocatalyst and visible light, cyclopropanation of an array of olefins, including trifluoromethyl- and pinacolatoboryl-substituted alkenes, can be accomplished in a matter of hours. The reaction is highly tolerant of traditionally reactive functional groups (carboxylic acids, basic heterocycles, alkyl halides, etc.) and permits the chemoselective cyclopropanation of polyolefinated compounds. Mechanistic interrogation revealed that the reaction proceeds via a rapid anionic 3-exo-tet ring closure, a pathway consistent with experimental and computational data.

Palladium-Catalyzed Carbonylative Cross-Coupling Reaction between Aryl(Heteroaryl) Iodides and Tricyclopropylbismuth: Expedient Access to Aryl Cyclopropylketones

The carbonylative cross-coupling reaction between aryl and heteroaryl iodides and tricyclopropylbismuth is reported. The reaction is catalyzed by (SIPr)Pd(allyl)Cl, a NHC-palladium(II) catalyst, operates under 1 atm of carbon monoxide and tolerates a wide range of functional groups. The use of lithium chloride was found to provide higher yields of the desired aryl cyclopropylketones. The conditions were also applied to the carbonylative cross-coupling of an iodoalkene to afford the corresponding alkenyl cyclopropylketone.

Aminofluorination of Cyclopropanes: A Multifold Approach through a Common, Catalytically Generated Intermediate

We have discovered a highly regioselective aminofluorination of cyclopropanes. Remarkably, four unique sets of conditions-two photochemical, two purely chemical-generated the same aminofluorinated adducts in good to excellent yields. The multiple, diverse ways in which the reaction could be initiated provided valuable clues that led to the proposal of a "unifying" chain propagation mechanism beyond initiation, tied by a common intermediate. In all, the proposed mechanism herein is substantiated by product distribution studies, kinetic analyses, LFERs, Rehm-Weller estimations of ΔGET, competition experiments, KIEs, fluorescence data, and DFT calculations. From a more physical standpoint, transient-absorption experiments have allowed direct spectroscopic observation of radical ion intermediates (previously only postulated or probed indirectly in photochemical fluorination systems) and, consequently, have provided kinetic support for chain propagation. Lastly, calculations suggest that solvent may play an important role in the cyclopropane ring-opening step.

OXADIAZINE COMPOUNDS AND METHODS OF USE THEREOF

The present disclosure relates to oxadiazine compounds, pharmaceutical compositions comprising an effective amount of an oxadiazine compound and methods for using an oxadiazine compound in the treatment of a neurodegenerative disease, comprising administering to a subject in need thereof an effective amount of an oxadiazine compound.

SUBSTITUTED PYRIMIDINE COMPOUNDS AS mPGES-1 INHIBITORS

The present disclosure is directed to substituted pyrimidine compounds of formula (I), and pharmaceutically acceptable salts thereof, as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and a

Facile synthesis of aryl(het)cyclopropane catalyzed by palladacycle

Sphos (2-dicyclohexylphosphino-2′,6′-dimethoxy-1,1′- biphenyl) adduct of cyclopalladated ferrocenylimine (IIe) exhibited highly catalytic activity for the Suzuki cross-coupling reaction of cyclopropylboronic acid with aryl(het) halides with 1 mol % catalyst loading. This process was applied to both of aryl and heteroaryl halides (Br and Cl), and made the various arylcyclopropane and heteroarylcyclopropane to be easily synthesized. A variety of substituents on the aryl halides, such as alkyl, acetyl, benzoyl, ether, formyl, carboxylate, methoxy, nitro and cyano were tolerated.

SLOW RELEASE OF ORGANOBORONIC ACIDS IN CROSS-COUPLING REACTIONS

A method of performing a chemical reaction includes reacting a compound selected from the group consisting of an organohalide and an organo-pseudohalide, and a protected organoboronic acid represented by formula (I) in a reaction mixture: R1-B-T; where R1 represents an organic group, T represents a conformationalIy rigid protecting group, and B represents boron having sp3 hybridization. When unprotected, the corresponding organoboronic acid is unstable by the boronic acid neat stability test. The reaction mixture further includes a base having a pKB of at least 1 and a pal ladium catalyst. The method further includes forming a cross-coupled product in the reaction mixture.

CYCLOPROPYL- AND CYCLOBUTYL-DIOXAZABOROCANE OR DIOXAZABORECANE DERIVATIVES

The present invention relates to borated cyclopropyl or cyclobutyl derivatives of formula (I) and to a process for their preparation in which the groups R1 and R2, n, m are as defined in claim 1. The derivatives can be used in particular for storing the corresponding boronic acid derivatives or as precursors of the boronic acid derivatives in Suzuki coupling reactions especially.

Chemical and biological investigation of cyclopropyl containing diaryl-pyrazole-3-carboxamides as novel and potent cannabinoid type 1 receptor antagonists

Obesity is a major clinical problem in the western world, and many molecular targets have been explored in the search for effective therapeutic agents. One of these, antagonism of the cannabinoid 1 (CB1) receptor, rose to prominence following reports demo