(R)-3-(4-Methoxy-phenyl)-2-((4S,5R)-2-oxo-4,5-diphenyl-oxazolidin-3-yl)-propionic acid benzyl ester

Base Information

Chemical Name:(R)-3-(4-Methoxy-phenyl)-2-((4S,5R)-2-oxo-4,5-diphenyl-oxazolidin-3-yl)-propionic acid benzyl ester
CAS No.:161633-99-4
Molecular Formula:C₃₂H₂₉NO₅
Molecular Weight:507.586
Hs Code.:

Synonyms:(R)-3-(4-Methoxy-phenyl)-2-((4S,5R)-2-oxo-4,5-diphenyl-oxazolidin-3-yl)-propionic acid benzyl ester

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Chemical Property of (R)-3-(4-Methoxy-phenyl)-2-((4S,5R)-2-oxo-4,5-diphenyl-oxazolidin-3-yl)-propionic acid benzyl ester

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of (R)-3-(4-Methoxy-phenyl)-2-((4S,5R)-2-oxo-4,5-diphenyl-oxazolidin-3-yl)-propionic acid benzyl ester

There total 3 articles about (R)-3-(4-Methoxy-phenyl)-2-((4S,5R)-2-oxo-4,5-diphenyl-oxazolidin-3-yl)-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 13139-86-1
4-methoxyphenyl magnesium bromide

: 161633-84-7
2-((4S,5R)-2-Oxo-4,5-diphenyl-oxazolidin-3-yl)-acrylic acid benzyl ester

: 161633-99-4
(R)-3-(4-Methoxy-phenyl)-2-((4S,5R)-2-oxo-4,5-diphenyl-oxazolidin-3-yl)-propionic acid benzyl ester

Guidance literature:: With copper(l) iodide; In tetrahydrofuran; a) -78 deg C, 120 min, b) -10 deg C, 30 min;
DOI:10.1021/ja00097a020

Reference yield:

: 161633-83-6
2-((4S,5R)-2-Oxo-4,5-diphenyl-oxazolidin-3-yl)-acrylic acid

: 161633-99-4
(R)-3-(4-Methoxy-phenyl)-2-((4S,5R)-2-oxo-4,5-diphenyl-oxazolidin-3-yl)-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / dimethylformamide / 19 h

2: 86 percent / CuI / tetrahydrofuran / a) -78 deg C, 120 min, b) -10 deg C, 30 min

With copper(l) iodide; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja00097a020

Reference yield:

: (4S,5R)-4,5-Diphenyl-3-(1-trimethylstannanyl-vinyl)-oxazolidin-2-one

: 161633-99-4
(R)-3-(4-Methoxy-phenyl)-2-((4S,5R)-2-oxo-4,5-diphenyl-oxazolidin-3-yl)-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) THF, Et₂O, pentane, hexane, -100 deg C, 30 min, 2.) THF, Et₂O, pentane, hexane, from -100 deg C to RT

2: Et₃N / dimethylformamide / 19 h

3: 86 percent / CuI / tetrahydrofuran / a) -78 deg C, 120 min, b) -10 deg C, 30 min

With copper(l) iodide; n-butyllithium; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja00097a020