(4aR,5R,6R)-N-(2-Iodobenzoyl)-5-iodo-2,3-dihydro-4H,7H-quinoline-4a,6-carbolactone

Base Information

Chemical Name:(4aR,5R,6R)-N-(2-Iodobenzoyl)-5-iodo-2,3-dihydro-4H,7H-quinoline-4a,6-carbolactone
CAS No.:171523-82-3
Molecular Formula:C₁₇H₁₅I₂NO₃
Molecular Weight:535.12
Hs Code.:

Synonyms:(4aR,5R,6R)-N-(2-Iodobenzoyl)-5-iodo-2,3-dihydro-4H,7H-quinoline-4a,6-carbolactone

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Chemical Property of (4aR,5R,6R)-N-(2-Iodobenzoyl)-5-iodo-2,3-dihydro-4H,7H-quinoline-4a,6-carbolactone

Chemical Property:

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Technology Process of (4aR,5R,6R)-N-(2-Iodobenzoyl)-5-iodo-2,3-dihydro-4H,7H-quinoline-4a,6-carbolactone

There total 5 articles about (4aR,5R,6R)-N-(2-Iodobenzoyl)-5-iodo-2,3-dihydro-4H,7H-quinoline-4a,6-carbolactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 609-67-6
2-Iodobenzoyl chloride

: 171523-75-4
(4aR,5R,6R)-5-Iodo-2,3,7,8-tetrahydro-4H-quinoline-4a,6-carbolactone

: 171523-82-3
(4aR,5R,6R)-N-(2-Iodobenzoyl)-5-iodo-2,3-dihydro-4H,7H-quinoline-4a,6-carbolactone

Guidance literature:: With triethylamine; In tetrahydrofuran; Ambient temperature;
DOI:10.1021/jo00129a052

Reference yield:

: 88-67-5
2-Iodobenzoic acid

: 171523-82-3
(4aR,5R,6R)-N-(2-Iodobenzoyl)-5-iodo-2,3-dihydro-4H,7H-quinoline-4a,6-carbolactone

Guidance literature:: Multi-step reaction with 2 steps

1: tionyl chloride / 2 h / Heating

2: 75 percent / Et₃N / tetrahydrofuran / Ambient temperature

With thionyl chloride; triethylamine; In tetrahydrofuran;
DOI:10.1021/jo00129a052

Reference yield:

: 171523-74-3
(2R,3R,4R)-1-Oxo-2-(3-azidopropyl)-3-iodocyclohexane-2,4-carbolactone

: 171523-82-3
(4aR,5R,6R)-N-(2-Iodobenzoyl)-5-iodo-2,3-dihydro-4H,7H-quinoline-4a,6-carbolactone

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / SnCl₂, NaHCO₃ / dioxane; H₂O / 1.) 7 h, room temp., 2.) 45 min.

2: 75 percent / Et₃N / tetrahydrofuran / Ambient temperature

With sodium hydrogencarbonate; triethylamine; tin(ll) chloride; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/jo00129a052