Methyl 3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-5-cyanopyrazole-4-carboxylate

Base Information

Chemical Name:Methyl 3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-5-cyanopyrazole-4-carboxylate
CAS No.:88287-69-8
Molecular Formula:C₃₂H₃₁N₃O₆
Molecular Weight:553.615
Hs Code.:

Synonyms:Methyl 3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-5-cyanopyrazole-4-carboxylate

Suppliers and Price of Methyl 3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-5-cyanopyrazole-4-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-5-cyanopyrazole-4-carboxylate

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Technology Process of Methyl 3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-5-cyanopyrazole-4-carboxylate

There total 1 articles about Methyl 3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-5-cyanopyrazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 31083-47-3
Methyl 3-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)-5-carbamoylpyrazole-4-carboxylate

: 88287-69-8
Methyl 3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-5-cyanopyrazole-4-carboxylate

Guidance literature:: With pyridine; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane; 1.) 0-5 deg C, 45 min, 2.) room temp., 18 h;
DOI:10.1021/jo00177a028

Reference yield: 93.0%

: 88287-69-8
Methyl 3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-5-cyanopyrazole-4-carboxylate

: 88287-72-3
3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-5-cyanopyrazole-4-carboxylic acid

Guidance literature:: With sodium hydroxide; In methanol; water; for 18h; Heating;
DOI:10.1021/jo00177a028

Reference yield:

: 88287-69-8
Methyl 3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-5-cyanopyrazole-4-carboxylate

: 80523-94-0
3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-5-aminopyrazolo<4,3-d>pyrimidine-7-thione

Guidance literature:: Multi-step reaction with 7 steps

1: 93 percent / NaOH / methanol; H₂O / 18 h / Heating

2: 76 percent / diphenyl phosphoryl azide, triethylamine / toluene / 1.5 h / Heating

3: 94 percent / Zn, NH₄Cl / methanol / 1.5 h / Heating

4: 94 percent / H₂S, triethylamine / pyridine

5: pyridine / toluene / 1.) 0 deg C, 1 h, 2.) room temp., 1 h

6: NH₄OH / methanol / 100 °C

7: NaOH / methanol; H₂O / 100 °C

With pyridine; ammonium hydroxide; sodium hydroxide; diphenyl phosphoryl azide; hydrogen sulfide; ammonium chloride; triethylamine; zinc; In pyridine; methanol; water; toluene;
DOI:10.1021/jo00177a028