88287-72-3

Upstream product

• 88287-69-8 Methyl 3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-5-cyanopyrazole-4-carboxylate 
• 117452-53-6 4-tert-butyloxycarbonyl-5-cyano-3-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)pyrazole 
• 31083-47-3 Methyl 3-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)-5-carbamoylpyrazole-4-carboxylate 
• 117475-65-7 4-tert-butyloxycarbonyl-5-ethoxycarbonyl-3-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)pyrazole 
• 117452-52-5 3-((2S,3S,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-5-carbamoyl-1H-pyrazole-4-carboxylic acid tert-butyl ester 
• 117469-21-3 tert-butyl (Z)-3-cyano-3-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)propenoate 
• 42890-06-2 (2R,3R,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)tetrahydrofuran-2-carboxylic acid 

Downstream Products

• 88295-39-0 3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-4-<<(2,2,2-trichloroethoxy)carbonyl>amino>pyrazole-5-carbonitrile 
• 117452-55-8 3-((2S,3S,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-5-cyano-1H-pyrazole-4-carbonyl chloride 
• 80523-94-0 3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-5-aminopyrazolo<4,3-d>pyrimidine-7-thione 
• 88287-80-3 3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-4-aminopyrazole-5-carbothiamide 
• 88287-84-7 4-(3-Benzoyl-2-benzyl-isothioureido)-5-((2S,3S,4R,5R)-3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-2H-pyrazole-3-carbothioic acid amide 
• 88287-85-8 N-[3-((2S,3S,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-7-thioxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-benzamide 
• 88287-86-9 3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-5-(benzylthio)-7-aminopyrazolo<4,3-d>pyrimidine 
• 117452-56-9 3-((2S,3S,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-5-cyano-1H-pyrazole-4-carbonyl azide 
• 117452-59-2 5-cyano-4-diazo-3-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)pyrazole 
• 117452-60-5 3-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)pyrazolo<4,3-d>pyrimidine-5,7-thione 
• 88287-77-8 3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-4-aminopyrazole-5-carbonitrile 

Relevant academic research and scientific papers

4-AMINO-3-(2,3,5-TRI-O-BENZYL-β-D-RIBOFURANOSYL)-5-PYRAZOLECARBONITRILE. SYNTHESIS AND CONVERSION INTO A SUGAR-BLOCKED 5,7-DISUBSTITUTED FORMYCIN ANALOG

The title compound, a potential intermediate to protected C-nucleoside analogs related to formycin A, was synthesized via a new route wherein 2,3,5-tri-O-benzyl-1-O-(p-nitrophenyl)-D-ribofuranose was converted to 2,5-anhydro-3,4,6-tri-O-benzyl-D-allonic a

Synthesis of 3-Glycofuranosyl-5-aminopyrazolopyrimidine-7-thiones: Thioguanosine-Type C-Nucleosides

The first C-nucleosides of the thioguanosine type are the 3-β-D-ribofuranosyl, 3-β-D-arabinofuranosyl, and 3-(2-deoxy-β-D-erythro-pentofuranosyl)derivatives of 5-aminopyrazolopyrimidine-7-thione.Synthesis of these products employed C6H5CH2SC(Cl)=NCOC6H5 as a new reagent for ring closure of the 3-glycofuranosyl-4-aminopyrazole-5-carbothiamide precursors.The new ring closure requires fewer steps and minimizes side reactions encountered in previous guanosine ring closure.The amino thioamide precursors are prepared from pyrazole C-nucleosides available as in previous formycin syntheses.