(E)-4-{2-[(E)-Benzyloxycarbonylmethylimino-methyl]-phenoxy}-but-2-enoic acid ethyl ester

Base Information

Chemical Name:(E)-4-{2-[(E)-Benzyloxycarbonylmethylimino-methyl]-phenoxy}-but-2-enoic acid ethyl ester
CAS No.:204640-68-6
Molecular Formula:C₂₂H₂₃NO₅
Molecular Weight:381.428
Hs Code.:

Synonyms:(E)-4-{2-[(E)-Benzyloxycarbonylmethylimino-methyl]-phenoxy}-but-2-enoic acid ethyl ester

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Chemical Property of (E)-4-{2-[(E)-Benzyloxycarbonylmethylimino-methyl]-phenoxy}-but-2-enoic acid ethyl ester

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Technology Process of (E)-4-{2-[(E)-Benzyloxycarbonylmethylimino-methyl]-phenoxy}-but-2-enoic acid ethyl ester

There total 3 articles about (E)-4-{2-[(E)-Benzyloxycarbonylmethylimino-methyl]-phenoxy}-but-2-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 83611-34-1
ethyl (E)-4-(2-formylphenoxy)but-2-enoate

: 120926-60-5
glycine benzyl ester trifluoroacetic salt

: 204640-68-6
(E)-4-{2-[(E)-Benzyloxycarbonylmethylimino-methyl]-phenoxy}-but-2-enoic acid ethyl ester

Guidance literature:: With 4 A molecular sieve; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 15h;
DOI:10.1021/jo9800210

Reference yield:

: 37746-78-4
4-bromo-trans-crotonic acid ethyl ester

: 204640-68-6
(E)-4-{2-[(E)-Benzyloxycarbonylmethylimino-methyl]-phenoxy}-but-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / dimethylformamide / 0.33 h / ice-cooling

1.2: 81 percent / dimethylformamide / 1 h / 20 °C

2.1: 80 percent / N,N-diisopropylethylamine; 4-Angstroem molecular sieves / CH₂Cl₂ / 15 h / 20 °C

With 4 A molecular sieve; sodium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; 1.1: Metallation / 1.2: Etherification / 2.1: Condensation;
DOI:10.1021/jo9800210

Reference yield:

: 89-95-2
2-methyl-benzyl alcohol

: 204640-68-6
(E)-4-{2-[(E)-Benzyloxycarbonylmethylimino-methyl]-phenoxy}-but-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / dimethylformamide / 0.33 h / ice-cooling

1.2: 81 percent / dimethylformamide / 1 h / 20 °C

2.1: 80 percent / N,N-diisopropylethylamine; 4-Angstroem molecular sieves / CH₂Cl₂ / 15 h / 20 °C

With 4 A molecular sieve; sodium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; 1.1: Metallation / 1.2: Etherification / 2.1: Condensation;
DOI:10.1021/jo9800210