O-(5-chloro-6,6-bis(2-nitrobenzyloxy)hexan-1-yl)-O'-cyanoethyl-N,N-diisopropylphosphoramidite

Base Information

Chemical Name:O-(5-chloro-6,6-bis(2-nitrobenzyloxy)hexan-1-yl)-O'-cyanoethyl-N,N-diisopropylphosphoramidite
CAS No.:1396698-25-1
Molecular Formula:C₂₉H₄₀ClN₄O₈P
Molecular Weight:639.085
Hs Code.:

Synonyms:O-(5-chloro-6,6-bis(2-nitrobenzyloxy)hexan-1-yl)-O'-cyanoethyl-N,N-diisopropylphosphoramidite

Suppliers and Price of O-(5-chloro-6,6-bis(2-nitrobenzyloxy)hexan-1-yl)-O'-cyanoethyl-N,N-diisopropylphosphoramidite

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of O-(5-chloro-6,6-bis(2-nitrobenzyloxy)hexan-1-yl)-O'-cyanoethyl-N,N-diisopropylphosphoramidite

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of O-(5-chloro-6,6-bis(2-nitrobenzyloxy)hexan-1-yl)-O'-cyanoethyl-N,N-diisopropylphosphoramidite

There total 2 articles about O-(5-chloro-6,6-bis(2-nitrobenzyloxy)hexan-1-yl)-O'-cyanoethyl-N,N-diisopropylphosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122934-55-8
5-formylpentyl benzoate

: 1396698-25-1
O-(5-chloro-6,6-bis(2-nitrobenzyloxy)hexan-1-yl)-O'-cyanoethyl-N,N-diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 4 steps

1: (1S)-10-camphorsulfonic acid; L-proline; N-chloro-succinimide / dichloromethane / 20 h / -10 °C / Inert atmosphere

2: 2,2-dimethoxy-propane; naphthalene-2-sulfonate / toluene / 48 h / 80 °C / Inert atmosphere

3: sodium hydroxide / methanol / 12 h / 20 °C

4: 1H-tetrazole / acetonitrile / 1 h / 20 °C

With 1H-tetrazole; N-chloro-succinimide; naphthalene-2-sulfonate; (1S)-10-camphorsulfonic acid; 2,2-dimethoxy-propane; L-proline; sodium hydroxide; In methanol; dichloromethane; toluene; acetonitrile;
DOI:10.1016/j.bmc.2012.07.030

Reference yield:

: 1396698-18-2
5-chloro-6-oxohexyl benzoate

: 1396698-25-1
O-(5-chloro-6,6-bis(2-nitrobenzyloxy)hexan-1-yl)-O'-cyanoethyl-N,N-diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 3 steps

1: 2,2-dimethoxy-propane; naphthalene-2-sulfonate / toluene / 48 h / 80 °C / Inert atmosphere

2: sodium hydroxide / methanol / 12 h / 20 °C

3: 1H-tetrazole / acetonitrile / 1 h / 20 °C

With 1H-tetrazole; naphthalene-2-sulfonate; 2,2-dimethoxy-propane; sodium hydroxide; In methanol; toluene; acetonitrile;
DOI:10.1016/j.bmc.2012.07.030

Reference yield:

: C₁₀H₁₃N₂O₅Pol

: 1396698-25-1
O-(5-chloro-6,6-bis(2-nitrobenzyloxy)hexan-1-yl)-O'-cyanoethyl-N,N-diisopropylphosphoramidite

: 5204-74-0
triethylammonium acetate

: O-(5-chloro-6,6-bis(2-nitrobenzyloxy)hexan-1-yl)-O'-cyanoethyl-N,N-diisopropylphosphoramidite

Guidance literature:: C₁₀H₁₃N₂O₅Pol; O-(5-chloro-6,6-bis(2-nitrobenzyloxy)hexan-1-yl)-O'-cyanoethyl-N,N-diisopropylphosphoramidite; for 0.166667h; CPG resin

With ammonium hydroxide; In water; at 55 ℃; for 16h; CPG resin

triethylammonium acetate; In acetonitrile;
DOI:10.1016/j.bmc.2012.07.030