3-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1H-pyrrole

Base Information

Chemical Name:3-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1H-pyrrole
CAS No.:637009-14-4
Molecular Formula:C₂₈H₃₅NO₄Si
Molecular Weight:477.676
Hs Code.:

3-[6-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-<i>d</i>][1,3]dioxol-4-yl]-1<i>H</i>-pyrrole

Synonyms:3-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1H-pyrrole

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Chemical Property of 3-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1H-pyrrole

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Technology Process of 3-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1H-pyrrole

There total 3 articles about 3-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 637009-13-3
3-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1-triisopropylsilanyl-1H-pyrrole

: 637009-14-4
3-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1H-pyrrole

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 0.166667h;
DOI:10.1055/s-2003-41026

Reference yield:

: 96690-02-7
5-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-D-ribofuranose

: 637009-14-4
3-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1H-pyrrole

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / Cs₂CO₃ / CH₂Cl₂ / 5 h / 18 °C

2: 21 percent / CaH₂; BF₃*OEt₂ / CH₂Cl₂ / 1 h / -50 °C

3: 77 percent / TBAF / tetrahydrofuran / 0.17 h / 0 °C

With calcium hydride; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; caesium carbonate; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-2003-41026

Reference yield:

: 478367-12-3
5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-β-ribofuranosyl trichloroacetamidate

: 637009-14-4
3-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1H-pyrrole

Guidance literature:: Multi-step reaction with 2 steps

1: 21 percent / CaH₂; BF₃*OEt₂ / CH₂Cl₂ / 1 h / -50 °C

2: 77 percent / TBAF / tetrahydrofuran / 0.17 h / 0 °C

With calcium hydride; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-2003-41026