2-[3-chloro-5-((R)-2,2,2-trifluoro-1-methylethoxymethyl)phenyl]-4,4,5,5-tetramethyl[1,3,2]dioxaborolane

Base Information

Chemical Name:2-[3-chloro-5-((R)-2,2,2-trifluoro-1-methylethoxymethyl)phenyl]-4,4,5,5-tetramethyl[1,3,2]dioxaborolane
CAS No.:1426408-86-7
Molecular Formula:C₁₆H₂₁BClF₃O₃
Molecular Weight:364.6
Hs Code.:

Synonyms:2-[3-chloro-5-((R)-2,2,2-trifluoro-1-methylethoxymethyl)phenyl]-4,4,5,5-tetramethyl[1,3,2]dioxaborolane

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Chemical Property of 2-[3-chloro-5-((R)-2,2,2-trifluoro-1-methylethoxymethyl)phenyl]-4,4,5,5-tetramethyl[1,3,2]dioxaborolane

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Technology Process of 2-[3-chloro-5-((R)-2,2,2-trifluoro-1-methylethoxymethyl)phenyl]-4,4,5,5-tetramethyl[1,3,2]dioxaborolane

There total 2 articles about 2-[3-chloro-5-((R)-2,2,2-trifluoro-1-methylethoxymethyl)phenyl]-4,4,5,5-tetramethyl[1,3,2]dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426408-85-6
1-chloro-3-((R)-2,2,2-trifluoro-1-methylethoxymethyl)benzene

: 73183-34-3
bis(pinacol)diborane

: 1426408-86-7
2-[3-chloro-5-((R)-2,2,2-trifluoro-1-methylethoxymethyl)phenyl]-4,4,5,5-tetramethyl[1,3,2]dioxaborolane

Guidance literature:: With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; for 13h; Inert atmosphere; Reflux;

Reference yield:

: 766-80-3
1-bromomethyl-3-chlorobenzene

: 1426408-86-7
2-[3-chloro-5-((R)-2,2,2-trifluoro-1-methylethoxymethyl)phenyl]-4,4,5,5-tetramethyl[1,3,2]dioxaborolane

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C / Inert atmosphere

1.2: 2.5 h / 0 - 20 °C / Inert atmosphere

2.1: 4,4'-di-tert-butyl-2,2'-bipyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tetrahydrofuran / 13 h / Inert atmosphere; Reflux

With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; sodium hydride; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; 2.1: |Suzuki Coupling;

Reference yield:

: 1426408-86-7
2-[3-chloro-5-((R)-2,2,2-trifluoro-1-methylethoxymethyl)phenyl]-4,4,5,5-tetramethyl[1,3,2]dioxaborolane

: 1426408-41-4
5-iodo-1-phenyl-1H-pyrazol-3-ylamine

: 1426408-87-8
5-[3-chloro-5-((R)-2,2,2-trifluoro-1-methylethoxymethyl)phenyl]-1-phenyl-1H-pyrazol-3-ylamine

Guidance literature:: With palladium diacetate; sodium carbonate; tricyclohexylphosphine; In 1,2-dimethoxyethane; water; at 100 ℃; for 2h; Inert atmosphere;