[3-((R)-5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-[3-(2-chloro-ethoxy)-[1,7]naphthyridin-8-yl]-amine

Base Information

Chemical Name:[3-((R)-5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-[3-(2-chloro-ethoxy)-[1,7]naphthyridin-8-yl]-amine
CAS No.:1429869-86-2
Molecular Formula:C₂₁H₁₉ClF₃N₅O₂
Molecular Weight:465.862
Hs Code.:

Synonyms:[3-((R)-5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-[3-(2-chloro-ethoxy)-[1,7]naphthyridin-8-yl]-amine

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Chemical Property of [3-((R)-5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-[3-(2-chloro-ethoxy)-[1,7]naphthyridin-8-yl]-amine

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Technology Process of [3-((R)-5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-[3-(2-chloro-ethoxy)-[1,7]naphthyridin-8-yl]-amine

There total 4 articles about [3-((R)-5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-[3-(2-chloro-ethoxy)-[1,7]naphthyridin-8-yl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262859-09-5
[(R)-5-(5-amino-2-fluoro-phenyl)-5-difluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester

: 1429869-87-3
3-(2-methoxy-ethoxy)-7H-[1,7]naphthyridin-8-one

: 1429869-85-1
[3-((R)-5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-[3-(2-methoxy-ethoxy)-[1,7]naphthyridin-8-yl]-amine

: 1429869-86-2
[3-((R)-5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-[3-(2-chloro-ethoxy)-[1,7]naphthyridin-8-yl]-amine

Guidance literature:: 3-(2-methoxy-ethoxy)-7H-[1,7]naphthyridin-8-one; With N-ethyl-N,N-diisopropylamine; trichlorophosphate; In toluene; at 125 ℃; for 48h;

[(R)-5-(5-amino-2-fluoro-phenyl)-5-difluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester; With hydrogenchloride; In 1,4-dioxane; tert-butyl alcohol; at 100 ℃; for 1h; Microwave irradiation;

Reference yield:

: 794592-13-5
5-bromo-3-methyl-pyridine-2-carboxylic acid ethyl ester

: 1429869-85-1
[3-((R)-5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-[3-(2-methoxy-ethoxy)-[1,7]naphthyridin-8-yl]-amine

: 1429869-86-2
[3-((R)-5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-[3-(2-chloro-ethoxy)-[1,7]naphthyridin-8-yl]-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride; copper(l) iodide / N,N-dimethyl-formamide; mineral oil / 8 h / 110 °C

1.2: 20 h / 100 °C

2.1: toluene / Reflux

3.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / Reflux

4.1: trichlorophosphate; N-ethyl-N,N-diisopropylamine / toluene / 48 h / 125 °C

4.2: 1 h / 100 °C / Microwave irradiation

With copper(l) iodide; potassium tert-butylate; sodium hydride; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1429870-17-6
5-(2-methoxy-ethoxy)-3-methyl-pyridine-2-carboxylic acid amide

: 1429869-85-1
[3-((R)-5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-[3-(2-methoxy-ethoxy)-[1,7]naphthyridin-8-yl]-amine

: 1429869-86-2
[3-((R)-5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-[3-(2-chloro-ethoxy)-[1,7]naphthyridin-8-yl]-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene / Reflux

2.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / Reflux

3.1: trichlorophosphate; N-ethyl-N,N-diisopropylamine / toluene / 48 h / 125 °C

3.2: 1 h / 100 °C / Microwave irradiation

With potassium tert-butylate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; toluene;