794592-13-5

Usage

Uses

Used in Pharmaceutical Industry:
5-Bromo-3-methylpyridine-2-carboxylic acid ethyl ester is used as a chemical intermediate for the synthesis of pharmaceutical agents, leveraging its capacity to alter the structure of bioactive molecules to improve their efficacy and safety profiles in medicinal applications.
Used in Chemical Industry:
In the chemical industry, 5-Bromo-3-methylpyridine-2-carboxylic acid ethyl ester is utilized as a building block in the creation of complex organic compounds, contributing to the development of new materials and chemical products with diverse applications.
Used in Drug Discovery and Development:
5-Bromo-3-methylpyridine-2-carboxylic acid ethyl ester is employed as a structural modifier in drug discovery processes, enhancing the pharmacological properties of potential drug candidates by adjusting their molecular frameworks to achieve desired therapeutic effects and minimize side effects.

Upstream product

• 156072-86-5 5-bromo-3-methylpyridine-2-carbonitrile 
• 3430-18-0 2,5-dibromo-3-methylpyridine 
• 3430-21-5 5-bromo-3-methyl-pyridin-2-ylamine 
• 1603-40-3 3-methylpyridin-2-ylamine 
• 64-17-5 ethanol 
• 886365-43-1 5-bromo-3-methylpyridine-2-carboxylic acid 

Downstream Products

• 1849594-85-9 C₉H₁₀BrNO₃ 
• 1429869-83-9 [3-((R)-5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-(3-bromo-[1,7]naphthyridin-8-yl)-amine 
• 1260670-05-0 3-bromo-8-chloro-[1,7]naphthyridine 
• 1375301-90-8 3-bromo-7H-[1,7]naphthyridin-8-one 
• 1400645-41-1 5-bromo-3-methyl-pyridine-2-carboxylic acid amide 
• 1429869-85-1 [3-((R)-5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-[3-(2-methoxy-ethoxy)-[1,7]naphthyridin-8-yl]-amine 
• 1429869-86-2 [3-((R)-5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-[3-(2-chloro-ethoxy)-[1,7]naphthyridin-8-yl]-amine 
• 1429869-84-0 8-[3-((R)-5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenylamino]-[1,7]naphthyridine-3-carbonitrile 

Relevant academic research and scientific papers

PYRIDINE-1,5-DIONES EXHIBITNG MNK INHIBITION AND THEIR METHOD OF USE

Compounds having activity as inhibitors of MNK are provided. One embodiment provides compounds having Structure (II): Formula (II) or a pharmaceutically acceptable salt, stereoisomer, tautomer, or prodrug thereof, wherein R1a, R1b, R2, X, Y, and L are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of MNK are also provided.

Design, synthesis and biological evaluation of pyridone–aminal derivatives as MNK1/2 inhibitors

Excessive phosphorylation of eukaryotic translation initiation factor 4E (eIF4E) plays a major role in the dysregulation of mRNA translation and the activation of tumor cell signaling. eIF4E is exclusively phosphorylated by mitogen-activated protein kinase interacting kinases 1 and 2 (MNK1/2) on Ser209. So, MNK1/2 inhibitors could decrease the level of p-eIF4E and regulate tumor-associated signaling pathways. A series of pyridone–aminal derivatives were synthesized and evaluated as MNK1/2 inhibitors. Several compounds exhibited great inhibitory activity against MNK1/2 and selected compounds showed moderate to excellent anti-proliferative potency against hematologic cancer cell lines. In particular, compound 42i (MNK1 IC50 = 7.0 nM; MNK2 IC50 = 6.1 nM) proved to be the most potent compound against TMD-8 cell line with IC50 value of 0.91 μM. Furthermore, 42i could block the phosphorylation level of eIF4E in CT-26 cell line, and 42i inhibited the tumor growth of CT-26 allograft model significantly. These results indicated that compound 42i was a promising MNK1/2 inhibitor for the potent treatment of colon cancer.