N-acetyl-1,2-dihydropyridyl acetic acid methyl ester

Base Information

• Chemical Name: N-acetyl-1,2-dihydropyridyl acetic acid methyl ester
• CAS No.: 1333121-03-1
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.218
• Mol file: 1333121-03-1.mol

Synonyms:N-acetyl-1,2-dihydropyridyl acetic acid methyl ester

Chemical Property of N-acetyl-1,2-dihydropyridyl acetic acid methyl ester

Chemical Property:

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Technology Process of N-acetyl-1,2-dihydropyridyl acetic acid methyl ester

There total 1 articles about N-acetyl-1,2-dihydropyridyl acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-(5-acetyl-2-phenyl-3-oxa-2,5-diazabicyclo[2.2.2]oct-7-en-6-yl)acetate → N-acetyl-1,2-dihydropyridyl acetic acid methyl ester (1333121-03-1) + methyl 2-(1-acetyl-6-hydroxy-3-(phenylamino)-1,2,3,6-tetrahydropyridin-2-yl)acetate + methyl 3-acetamido-3-(1-phenyl-1H-pyrrol-2-yl)propanoate (1445609-07-3)

Guidance literature:

With bis(cyclopentadienyl)titanium dichloride; zinc; In tetrahydrofuran; ethanol; at -30 - 20 ℃; for 20h; Solvent; Schlenk technique; Inert atmosphere;

DOI:10.1021/jo4009996

Reference yield: 65.0%

N-hydroxy-2-phenylacetamide (5330-97-2) + N-acetyl-1,2-dihydropyridyl acetic acid methyl ester (1333121-03-1) → methyl 2-(5-acetyl-3-(2-phenylacetyl)-2-oxa-3,5-diazabicyclo[2.2.2]oct-7-en-6-yl)acetate

Guidance literature:

With sodium periodate; In methanol; water; at 0 ℃; for 3h; regioselective reaction;

DOI:10.1021/ol202027k

Reference yield: 30.0%

tert-Butyl N-hydroxycarbamate (36016-38-3) + N-acetyl-1,2-dihydropyridyl acetic acid methyl ester (1333121-03-1) → methyl 2-(5-acetyl-3-(2-phenylacetyl)-2-oxa-3,5-diazabicyclo[2.2.2]oct-7-en-6-yl)acetate + methyl 2-(1-acetyl-3-(tert-butoxycarbonyl(hydroxy)amino)-6-oxo-1,2,3,6-tetrahydropyridin-2-y)acetate

Guidance literature:

tert-Butyl N-hydroxycarbamate; N-acetyl-1,2-dihydropyridyl acetic acid methyl ester; With copper dichloride; In tetrahydrofuran; for 0.0833333h;

With dihydrogen peroxide; In tetrahydrofuran; regioselective reaction;

DOI:10.1021/ol202027k