3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(2E)-propenoyl methyl carbonate

Base Information

Chemical Name:3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(2E)-propenoyl methyl carbonate
CAS No.:1005003-77-9
Molecular Formula:C₂₀H₂₂FN₃O₆S
Molecular Weight:451.476
Hs Code.:

Synonyms:3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(2E)-propenoyl methyl carbonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(2E)-propenoyl methyl carbonate

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Technology Process of 3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(2E)-propenoyl methyl carbonate

There total 1 articles about 3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(2E)-propenoyl methyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 912337-58-7
3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(2E)-propenoic acid

: 79-22-1
methyl chloroformate

: 1005003-77-9
3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(2E)-propenoyl methyl carbonate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 25 ℃; for 0.666667h;

Reference yield: 98.0%

: 1005003-77-9
3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(2E)-propenoyl methyl carbonate

: 910867-08-2
(E)-N-(4-(4-fluorophenyl)-5-(3-hydroxyprop-1-en-1-yl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide

Guidance literature:: 3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(2E)-propenoyl methyl carbonate; With lithium aluminium tetrahydride; In tetrahydrofuran; at -50 - 20 ℃; for 0.75h;

With hydrogenchloride; In tetrahydrofuran; water; Product distribution / selectivity;