N-(4-trifluoromethoxy-phenyl)-2-chloro-4-fluoro-5-nitro-benzoic acid amide

Base Information

• Chemical Name: N-(4-trifluoromethoxy-phenyl)-2-chloro-4-fluoro-5-nitro-benzoic acid amide
• CAS No.: 1380836-83-8
• Molecular Formula: C₁₄H₇ClF₄N₂O₄
• Molecular Weight: 378.667
• Mol file: 1380836-83-8.mol

Synonyms:N-(4-trifluoromethoxy-phenyl)-2-chloro-4-fluoro-5-nitro-benzoic acid amide

Chemical Property of N-(4-trifluoromethoxy-phenyl)-2-chloro-4-fluoro-5-nitro-benzoic acid amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-trifluoromethoxy-phenyl)-2-chloro-4-fluoro-5-nitro-benzoic acid amide

There total 2 articles about N-(4-trifluoromethoxy-phenyl)-2-chloro-4-fluoro-5-nitro-benzoic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-(trifluoromethoxy)aniline (461-82-5) + 2-chloro-4-fluoro-5-nitrobenzoyl chloride (120890-66-6) → N-(4-trifluoromethoxy-phenyl)-2-chloro-4-fluoro-5-nitro-benzoic acid amide (1380836-83-8)

Guidance literature:

4-(trifluoromethoxy)aniline; 2-chloro-4-fluoro-5-nitrobenzoyl chloride; With triethylamine; In tetrahydrofuran; for 1h;

With potassium sulfate; In tetrahydrofuran; pH=3; Cooling with ice;

Reference yield:

2-chloro-4-fluoro-5-nitrobenzoic acid (114776-15-7) → N-(4-trifluoromethoxy-phenyl)-2-chloro-4-fluoro-5-nitro-benzoic acid amide (1380836-83-8)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 3 h / Reflux

2: triethylamine / tetrahydrofuran / 1 h

With thionyl chloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

Reference yield: 97.0%

N-(4-trifluoromethoxy-phenyl)-2-chloro-4-fluoro-5-nitro-benzoic acid amide (1380836-83-8) + 1-Amino-2-methyl-propan-2-ol (2854-16-2) → N-(4-trifluoromethoxy-phenyl)-2-chloro-4-(2-hydroxy-2-methyl-propylamino)-5-nitro-benzoic acid amide (1380836-85-0)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 1h;

upstream raw materials:

4-(trifluoromethoxy)aniline

2-chloro-4-fluoro-5-nitrobenzoyl chloride

2-chloro-4-fluoro-5-nitrobenzoic acid

Downstream raw materials:

N-(4-trifluoromethoxy-phenyl)-2-chloro-4-(2-hydroxy-2-methyl-propylamino)-5-nitro-benzoic acid amide