3-(4-chloro-3-nitro-phenyl)-N-[3-(2-oxo-pyrrolidin-1-yl)-propyl]-acrylamide

Base Information

Chemical Name:3-(4-chloro-3-nitro-phenyl)-N-[3-(2-oxo-pyrrolidin-1-yl)-propyl]-acrylamide
CAS No.:280752-92-3
Molecular Formula:C₁₆H₁₈ClN₃O₄
Molecular Weight:351.79
Hs Code.:

3-(4-chloro-3-nitro-phenyl)-<i>N</i>-[3-(2-oxo-pyrrolidin-1-yl)-propyl]-acrylamide

Synonyms:3-(4-chloro-3-nitro-phenyl)-N-[3-(2-oxo-pyrrolidin-1-yl)-propyl]-acrylamide

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Chemical Property of 3-(4-chloro-3-nitro-phenyl)-N-[3-(2-oxo-pyrrolidin-1-yl)-propyl]-acrylamide

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Technology Process of 3-(4-chloro-3-nitro-phenyl)-N-[3-(2-oxo-pyrrolidin-1-yl)-propyl]-acrylamide

There total 1 articles about 3-(4-chloro-3-nitro-phenyl)-N-[3-(2-oxo-pyrrolidin-1-yl)-propyl]-acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7663-77-6
1-(3-aminopropyl)-2-pyrrolidone

: 20797-48-2,199679-38-4
(E)-4-chloro-3-nitrocinnamic acid

: 280752-92-3
3-(4-chloro-3-nitro-phenyl)-N-[3-(2-oxo-pyrrolidin-1-yl)-propyl]-acrylamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1021/jm0002782

Reference yield:

: 1122-41-4
2,4-dichlorobenzenethiol

: 280752-92-3
3-(4-chloro-3-nitro-phenyl)-N-[3-(2-oxo-pyrrolidin-1-yl)-propyl]-acrylamide

: 280749-00-0
(2,4-dichlorophenyl)[2-nitro-4-(E-((3-(2-oxopyrrolidin-1-yl)propylamino)carbonyl)ethenyl)phenyl]sulfide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1021/jm0002782

Reference yield:

: 280752-92-3
3-(4-chloro-3-nitro-phenyl)-N-[3-(2-oxo-pyrrolidin-1-yl)-propyl]-acrylamide

: 280752-58-1
(2,4-dichlorophenyl)[2-amino-4-(E-((3-(2-oxopyrrolidin-1-yl)propylamino)carbonyl)ethenyl)phenyl]sulfide

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide / 1 h / 20 °C

2: SnCl₂; EtOH / Heating

With ethanol; potassium carbonate; tin(ll) chloride; In N,N-dimethyl-formamide; 1: Substitution / 2: Reduction;
DOI:10.1021/jm0002782