(2S,4R)-2-tert-Butoxycarbonylamino-4-methyl-pentanedioic acid 5-benzyl ester

Base Information

Chemical Name:(2S,4R)-2-tert-Butoxycarbonylamino-4-methyl-pentanedioic acid 5-benzyl ester
CAS No.:94846-95-4
Molecular Formula:C₁₈H₂₅NO₆
Molecular Weight:351.4
Hs Code.:

Synonyms:(2S,4R)-2-tert-Butoxycarbonylamino-4-methyl-pentanedioic acid 5-benzyl ester

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Chemical Property of (2S,4R)-2-tert-Butoxycarbonylamino-4-methyl-pentanedioic acid 5-benzyl ester

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Technology Process of (2S,4R)-2-tert-Butoxycarbonylamino-4-methyl-pentanedioic acid 5-benzyl ester

There total 5 articles about (2S,4R)-2-tert-Butoxycarbonylamino-4-methyl-pentanedioic acid 5-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 592532-50-8
(2R,4S)-4-tert-Butoxycarbonylamino-5-hydroxy-2-methyl-pentanoic acid benzyl ester

: 94846-95-4
(2S,4R)-2-tert-Butoxycarbonylamino-4-methyl-pentanedioic acid 5-benzyl ester

Guidance literature:: With jones reagent; In acetone; at 0 - 20 ℃;
DOI:10.1021/ol035125y

Reference yield:

: 100-39-0
benzyl bromide

: 94846-95-4
(2S,4R)-2-tert-Butoxycarbonylamino-4-methyl-pentanedioic acid 5-benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / Cs₂CO₃ / acetone / 1 h / 30 °C

2: 85 percent / aq. AcOH; TBAF / tetrahydrofuran / 0 - 20 °C

3: Jones reagent / acetone / 0 - 20 °C

With jones reagent; tetrabutyl ammonium fluoride; caesium carbonate; acetic acid; In tetrahydrofuran; acetone;
DOI:10.1021/ol035125y

Reference yield:

: 138871-61-1
(3R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-methyl-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester

: 94846-95-4
(2S,4R)-2-tert-Butoxycarbonylamino-4-methyl-pentanedioic acid 5-benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: aq. LiOH / dioxane / 3 h / 0 °C

2: 83 percent / Cs₂CO₃ / acetone / 1 h / 30 °C

3: 85 percent / aq. AcOH; TBAF / tetrahydrofuran / 0 - 20 °C

4: Jones reagent / acetone / 0 - 20 °C

With lithium hydroxide; jones reagent; tetrabutyl ammonium fluoride; caesium carbonate; acetic acid; In tetrahydrofuran; 1,4-dioxane; acetone;
DOI:10.1021/ol035125y