3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}-phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl acetate

Base Information

Chemical Name:3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}-phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl acetate
CAS No.:1036712-87-4
Molecular Formula:C₃₀H₃₁FN₆O₅
Molecular Weight:574.612
Hs Code.:

Synonyms:3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}-phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl acetate

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Chemical Property of 3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}-phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl acetate

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Technology Process of 3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}-phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl acetate

There total 5 articles about 3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}-phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1036712-77-2
4-{4-[({3-tert-butyl-1-[3-(hydroxymethyl)phenyl]-1H-pyrazol-5-yl}carbamoyl)amino]-3-fluorophenoxy}-N-methylpyridine-2-carboxamide

: 75-36-5
acetyl chloride

: 1036712-87-4
3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}-phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl acetate

Guidance literature:: In dichloromethane; at 0 ℃; for 1h;

Reference yield:

: 1036712-94-3
ethyl 3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)-pyridin-4-yl]oxy}phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzoate

: 1036712-87-4
3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}-phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl acetate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / ethanol / 20 °C

2: dichloromethane / 1 h / 0 °C

With sodium tetrahydroborate; In ethanol; dichloromethane;

Reference yield:

: 725685-92-7
3-(5-amino-3-tert-butyl-pyrazol-1-yl)-benzoic acid ethyl ester

: 1036712-87-4
3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}-phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / tetrahydrofuran / 20 °C

2: triethylamine / tetrahydrofuran / 20 °C

3: sodium tetrahydroborate / ethanol / 20 °C

4: dichloromethane / 1 h / 0 °C

With sodium tetrahydroborate; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane;