INDOMETHACIN ACYL-B-D-GLUCURONIDE

Base Information

• Chemical Name: INDOMETHACIN ACYL-B-D-GLUCURONIDE
• CAS No.: 75523-11-4
• Molecular Formula: C25H24 Cl N O10
• Molecular Weight: 533.919
• Hs Code.: 29389090
• Mol file: 75523-11-4.mol

Synonyms:Indomethacinglucuronide

Chemical Property of INDOMETHACIN ACYL-B-D-GLUCURONIDE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 82-84°C
• Refractive Index: 1.664
• Boiling Point: 708.474°C at 760 mmHg
• Flash Point: 382.271°C
• PSA: 164.75000
• Density: 1.574g/cm³
• LogP: 1.27810
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

Purity/Quality:

98% ^*data from raw suppliers

Indomethacin acyl-b-D-glucuronide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Indomethacin Acyl-β-D-glucuronide is a metabolite of Indomethacin (I641000). Acyl glucuronides have been implicated in the toxicity of many xenobiotics and marketed drugs.

Technology Process of INDOMETHACIN ACYL-B-D-GLUCURONIDE

There total 3 articles about INDOMETHACIN ACYL-B-D-GLUCURONIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 4-[2-(diethoxy-phosphoryloxy)-ethyl]-phenyl ester (1428774-23-5) + UDP-glucuronic acid (1245697-26-0,106864-00-0,14520-48-0,30329-32-9,3545-73-1,5918-40-1) → C12H19O5P + Indomethacin glucuronide (75523-11-4) + [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid (53-86-1)

Guidance literature:

With magnesium chloride; alamethicin; In aq. buffer; at 37 ℃; pH=7.5; Time; Enzymatic reaction;

DOI:10.1016/j.bcp.2013.01.031

Reference yield:

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid (53-86-1) + UDP-glucuronic acid (1245697-26-0,106864-00-0,14520-48-0,30329-32-9,3545-73-1,5918-40-1) → Indomethacin glucuronide (75523-11-4)

Guidance literature:

With diisopropyl phosphofluoridate; magnesium chloride; alamethicin; In aq. buffer; at 37 ℃; pH=7.5; Reagent/catalyst; Enzymatic reaction;

DOI:10.1016/j.bcp.2013.01.031

Reference yield:

[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 4-[2-(diethoxy-phosphoryloxy)-ethyl]-phenyl ester (1428774-23-5) → Indomethacin glucuronide (75523-11-4)

Guidance literature:

Multi-step reaction with 2 steps

1: NADP; β-D-glucose 6-phosphate; magnesium chloride; glucose-6-phosphate dehydrogenase / aq. phosphate buffer / 3 h / 37 °C / pH 7.4 / Enzymatic reaction

2: magnesium chloride; diisopropyl phosphofluoridate; alamethicin / aq. buffer / 37 °C / pH 7.5 / Enzymatic reaction

With glucose-6-phosphate dehydrogenase; diisopropyl phosphofluoridate; β-D-glucose 6-phosphate; NADP; magnesium chloride; alamethicin; In aq. phosphate buffer;

DOI:10.1016/j.bcp.2013.01.031

upstream raw materials:

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

UDP-glucuronic acid

[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 4-[2-(diethoxy-phosphoryloxy)-ethyl]-phenyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 75523-11-4 INDOMETHACIN ACYL-B-D-GLUCURONIDE

Send

Send

Metric Ton KG G Pound L ML

Send

Send