(E)-3-(2-acetylamino-4-chloro-5-fluoro-phenyl)-acrylic acid t-butyl ester

Base Information

Chemical Name:(E)-3-(2-acetylamino-4-chloro-5-fluoro-phenyl)-acrylic acid t-butyl ester
CAS No.:868408-82-6
Molecular Formula:C₁₅H₁₇ClFNO₃
Molecular Weight:313.756
Hs Code.:

Synonyms:(E)-3-(2-acetylamino-4-chloro-5-fluoro-phenyl)-acrylic acid t-butyl ester

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Chemical Property of (E)-3-(2-acetylamino-4-chloro-5-fluoro-phenyl)-acrylic acid t-butyl ester

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Technology Process of (E)-3-(2-acetylamino-4-chloro-5-fluoro-phenyl)-acrylic acid t-butyl ester

There total 1 articles about (E)-3-(2-acetylamino-4-chloro-5-fluoro-phenyl)-acrylic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85462-63-1
N-(2-bromo-5-chloro-4-fluoro-phenyl)-acetamide

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 868408-82-6
(E)-3-(2-acetylamino-4-chloro-5-fluoro-phenyl)-acrylic acid t-butyl ester

Guidance literature:: With triethylamine; palladium diacetate; tris-(o-tolyl)phosphine; In DMF (N,N-dimethyl-formamide); at 100 ℃; for 16h;

Reference yield:

: 868408-82-6
(E)-3-(2-acetylamino-4-chloro-5-fluoro-phenyl)-acrylic acid t-butyl ester

: 868407-62-9
(E)-3-(2-acetylamino-4-chloro-5-fluoro-phenyl)-acrylic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 0.5h;

Reference yield:

: 868408-82-6
(E)-3-(2-acetylamino-4-chloro-5-fluoro-phenyl)-acrylic acid t-butyl ester

: 868408-80-4
N-(5-chloro-4-fluoro-2-{(E)-3-[3-(4-fluoro-benzyl)-3,8-diaza-bicyclo[3.2.1]oct-8-yl]-3-oxo-propenyl}-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 0.5 h

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / DMF (N,N-dimethyl-formamide) / 16 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In DMF (N,N-dimethyl-formamide); dichloromethane;