6-chloro-1,2-dihydro-3-hydroxy-1-methyl-2-oxo-4-phenylquinoline

Base Information

• Chemical Name: 6-chloro-1,2-dihydro-3-hydroxy-1-methyl-2-oxo-4-phenylquinoline
• CAS No.: 37393-79-6
• Molecular Formula: C₁₆H₁₂ClNO₂
• Molecular Weight: 285.73
• Mol file: 37393-79-6.mol

Synonyms:6-chloro-1,2-dihydro-3-hydroxy-1-methyl-2-oxo-4-phenylquinoline

Chemical Property of 6-chloro-1,2-dihydro-3-hydroxy-1-methyl-2-oxo-4-phenylquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 6-chloro-1,2-dihydro-3-hydroxy-1-methyl-2-oxo-4-phenylquinoline

There total 4 articles about 6-chloro-1,2-dihydro-3-hydroxy-1-methyl-2-oxo-4-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N-(4-chlorophenyl)-2-cyano-N-methyl-3-phenyloxirane-2-carboxamide (1134192-52-1) → 6-chloro-1,2-dihydro-3-hydroxy-1-methyl-2-oxo-4-phenylquinoline (37393-79-6)

Guidance literature:

N-(4-chlorophenyl)-2-cyano-N-methyl-3-phenyloxirane-2-carboxamide; With sulfuric acid; In acetonitrile; at 0 - 20 ℃;

With sodium hydroxide; In acetonitrile; at 0 - 20 ℃;

DOI:10.1021/ol900255g

Reference yield: 65.0%

2-(2-chloro-N-methyl-acetamido)-5-chlorobenzophenone (6021-21-2) → 6-chloro-1,2-dihydro-3-hydroxy-1-methyl-2-oxo-4-phenylquinoline (37393-79-6) + 3-amino-6-chloro-1,2-dihydro-1-methyl-2-oxo-4-phenylquinoline (5220-02-0) + 3,6-dichloro-1,2-dihydro-1-methyl-2-oxo-4-phenylquinoline + diazepam (439-14-5)

Guidance literature:

With ammonia; In ethanol; at 80 ℃; for 2h; Further byproducts given;

Reference yield: 65.0%

2-(2-chloro-N-methyl-acetamido)-5-chlorobenzophenone (6021-21-2) → 6-chloro-3,4-epoxy-1,2,3,4-tetrahydro-1-methyl-2-oxo-4-phenylquinoline (37393-81-0) + 6-chloro-1,2-dihydro-3-hydroxy-1-methyl-2-oxo-4-phenylquinoline (37393-79-6) + 3-amino-6-chloro-1,2-dihydro-1-methyl-2-oxo-4-phenylquinoline (5220-02-0) + 3,6-dichloro-1,2-dihydro-1-methyl-2-oxo-4-phenylquinoline + 6-Chloro-3-methyl-7b-phenyl-1,1a,3,7b-tetrahydro-1,3-diaza-cyclopropa[a]naphthalen-2-one + diazepam (439-14-5)

Guidance literature:

With ammonia; In ethanol; at 80 ℃; for 2h; Mechanism; further reagent;

upstream raw materials:

2-(2-chloro-N-methyl-acetamido)-5-chlorobenzophenone

N-(4-chlorophenyl)-2-cyano-N-methyl-3-phenyloxirane-2-carboxamide