2-benzyloxy-5-(2-bromoacetylaminopyridin-5-yl)-6-methyl-3-pyridinecarbonitrile

Base Information

Chemical Name:2-benzyloxy-5-(2-bromoacetylaminopyridin-5-yl)-6-methyl-3-pyridinecarbonitrile
CAS No.:141354-39-4
Molecular Formula:C₂₁H₁₇BrN₄O₂
Molecular Weight:437.296
Hs Code.:

Synonyms:2-benzyloxy-5-(2-bromoacetylaminopyridin-5-yl)-6-methyl-3-pyridinecarbonitrile

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Chemical Property of 2-benzyloxy-5-(2-bromoacetylaminopyridin-5-yl)-6-methyl-3-pyridinecarbonitrile

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Technology Process of 2-benzyloxy-5-(2-bromoacetylaminopyridin-5-yl)-6-methyl-3-pyridinecarbonitrile

There total 7 articles about 2-benzyloxy-5-(2-bromoacetylaminopyridin-5-yl)-6-methyl-3-pyridinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 141354-57-6
5-(2-aminopyridin-5-yl)-2-benzyloxy-6-methyl-3-pyridinecarbonitrile

: 598-21-0
2-Bromoacetyl bromide

: 141354-39-4
2-benzyloxy-5-(2-bromoacetylaminopyridin-5-yl)-6-methyl-3-pyridinecarbonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1248/cpb.40.666

Reference yield:

: 106730-54-5
olprinone

: 141354-39-4
2-benzyloxy-5-(2-bromoacetylaminopyridin-5-yl)-6-methyl-3-pyridinecarbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 46 percent / K₂CO₃ / dimethylformamide / 0.5 h / 90 °C

2: 1.) O₃, 2.) aq. sodium sulfite / 1.) AcOEt, -60 deg C, 15 min, 2.) AcOEt

3: 85 percent / 80percent NH₂NH₂*H₂O, AcOH / 2 h / 100 °C

4: 61 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 2 h / 0 °C

With potassium carbonate; ozone; hydrazine hydrate; acetic acid; N-ethyl-N,N-diisopropylamine; sodium sulfite; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.40.666

Reference yield:

: 22379-62-0
potassium benzyloxide

: 141354-39-4
2-benzyloxy-5-(2-bromoacetylaminopyridin-5-yl)-6-methyl-3-pyridinecarbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / 4 h / Heating

2: 1.) O₃, 2.) aq. sodium sulfite / 1.) AcOEt, -60 deg C, 15 min, 2.) AcOEt

3: 85 percent / 80percent NH₂NH₂*H₂O, AcOH / 2 h / 100 °C

4: 61 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 2 h / 0 °C

With ozone; hydrazine hydrate; acetic acid; N-ethyl-N,N-diisopropylamine; sodium sulfite; In dichloromethane;
DOI:10.1248/cpb.40.666