106730-54-5 Usage
Description
Olprinone is a phosphodiesterase III inhibitor, a medication with potential therapeutic applications in cardiovascular conditions. It functions by elevating the levels of cyclic adenosine monophosphate (cAMP) in the heart and blood vessels, which results in vasodilation and positive inotropic effects. These actions contribute to the improvement of cardiac function and an increase in cardiac output, particularly beneficial for patients suffering from heart failure. Additionally, Olprinone exhibits anti-inflammatory and anti-platelet properties, broadening its utility in the treatment of various cardiovascular diseases. However, its use requires careful monitoring due to potential side effects such as hypotension, arrhythmias, and thrombocytopenia.
Uses
Used in Cardiology:
Olprinone is used as a treatment for heart failure, aiming to improve cardiac function and increase cardiac output by increasing cAMP levels, leading to vasodilation and positive inotropic effects.
Used in Cardiovascular Medicine:
Olprinone is utilized for its anti-inflammatory and anti-platelet effects, making it a potentially useful medication for patients with a range of cardiovascular conditions, where these properties can contribute to better management of the disease.
Check Digit Verification of cas no
The CAS Registry Mumber 106730-54-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,6,7,3 and 0 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 106730-54:
(8*1)+(7*0)+(6*6)+(5*7)+(4*3)+(3*0)+(2*5)+(1*4)=105
105 % 10 = 5
So 106730-54-5 is a valid CAS Registry Number.
InChI:InChI=1/C14H10N4O/c1-9-12(6-11(7-15)14(19)17-9)10-2-3-13-16-4-5-18(13)8-10/h2-6,8H,1H3,(H,17,19)
106730-54-5Relevant articles and documents
Olprinone hydrochloride compound preparation method
-
, (2019/04/17)
The invention discloses an olprinone hydrochloride compound preparation method. 6-bromoimidazo[1,2-a]pyridine is used as a starting material to prepare an olprinone hydrochloride compound through Grignard reaction, ozone oxidation, additive reaction, closed-loop reaction, salification and refining. The preparation process is mild in reaction condition, technically stable, high in repeatability andproduct yield, less in impurity and suitable for industrial production.
Imidazo[1,2-a]pyridines. Synthesis and inotropic activity of new 5-imidazo[1,2-a]pyridinyl-2(1H)-pyridinone derivatives
Yamanaka,Miyake,Suda,Ohhara,Ogawa
, p. 1556 - 1567 (2007/10/02)
A series of 1,2-dihydro-5-imidazo[1,2-a]pyridinyl-2(1H)-pyridinones was synthesized and evaluated for positive inotropic activity. 1,2-Dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-3- pyridinecarbonitrile (11a) hydrochloride monohydrate (E-1020) was found to be a potent and selective inhibitor of phosphodiesterase III and a long-acting, potent, orally active positive inotropic agent. Additional imidazo[1,2-a]pyridin-2-yl (3a), -3-yl (16), -7-yl (20) and -8-yl (24a) compounds were also prepared. Altering the pyridine substitution from the 2-position to the 6-position produced a 2-fold increase in the i.v. cardiotonic potency (ED50) from 52 to 23 μg/kg, while substitution at the 3-, 7- or 8-position reduced potency. In the 2-positional isomers, introduction of halogen groups enhanced the activity and 3-chloro-1,2-dihydro-5-(6-fluoroimidazo[1,2-a]pyridin-2-yl)-6-methyl-2(1H)- pyridinone (3a) was the most potent (i.v. ED50 11 μg/kg) in this seris. E-1020 is presently under development for the treatment of congestive heart failure.
