Pyrazine, 2,3-dimethyl-5-(2-methylbutyl)- (9CI)

Base Information

• Chemical Name: Pyrazine, 2,3-dimethyl-5-(2-methylbutyl)- (9CI)
• CAS No.: 75492-01-2
• Molecular Formula: C₁₁H₁₈N₂
• Molecular Weight: 178.277
• Hs Code.: 2933990090
• Mol file: 75492-01-2.mol

Synonyms:2,3-Dimethyl-5-(2-methylbutyl)pyrazine

Chemical Property of Pyrazine, 2,3-dimethyl-5-(2-methylbutyl)- (9CI)

Chemical Property:

• Refractive Index: n20/D1.494
• Flash Point: 99℃
• PSA: 25.78000
• Density: 0.927 g/mL at 25 °C
• LogP: 2.68200

Purity/Quality:

95+% ^*data from raw suppliers

2,3-Dimethyl-5-(2-methylbutyl)pyrazine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrazine, 2,3-dimethyl-5-(2-methylbutyl)- (9CI)

There total 2 articles about Pyrazine, 2,3-dimethyl-5-(2-methylbutyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-methylbutylzinc bromide (681248-31-7) + 2,3-dimethyl-5-trifluoromethanesulfonyloxypyrazine (1147535-04-3) → 5-(2-Methyl-butyl)-2,3-dimethyl-pyrazin (75492-01-2)

Guidance literature:

With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1055/s-0031-1290972

Reference yield:

5,6-dimethyl-2-hydroxypyrazine (57229-36-4) → 5-(2-Methyl-butyl)-2,3-dimethyl-pyrazin (75492-01-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / chloroform / 2.5 h / -78 - 20 °C / Inert atmosphere

2: 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

With pyridine; 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); In tetrahydrofuran; chloroform; 2: Negishi coupling reaction;

DOI:10.1055/s-0031-1290972

upstream raw materials:

2-methylbutylzinc bromide

2,3-dimethyl-5-trifluoromethanesulfonyloxypyrazine

5,6-dimethyl-2-hydroxypyrazine