2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3,3-difluoro-3-(N-methylcarbamoyl)-2-oxopropyl]acetamide

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Chemical Name:2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3,3-difluoro-3-(N-methylcarbamoyl)-2-oxopropyl]acetamide
CAS No.:339169-58-3
Molecular Formula:C₃₃H₃₁F₂N₅O₆
Molecular Weight:631.636
Hs Code.:

Synonyms:2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3,3-difluoro-3-(N-methylcarbamoyl)-2-oxopropyl]acetamide

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Chemical Property of 2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3,3-difluoro-3-(N-methylcarbamoyl)-2-oxopropyl]acetamide

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Technology Process of 2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3,3-difluoro-3-(N-methylcarbamoyl)-2-oxopropyl]acetamide

There total 5 articles about 2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3,3-difluoro-3-(N-methylcarbamoyl)-2-oxopropyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 339169-57-2
2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3,3-difluoro-2-hydroxy-3-(N-methylcarbamoyl)propyl]acetamide

: 339169-58-3
2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3,3-difluoro-3-(N-methylcarbamoyl)-2-oxopropyl]acetamide

Guidance literature:: With Dess-Martin periodane; In N,N-dimethyl-formamide; at 20 ℃; for 14h;
DOI:10.1021/jm000497n

Reference yield:

: 59830-60-3,63219-70-5,68474-26-0
N-benzyloxycarbonyl-2-amino-3-phenylpropionaldehyde

: 339169-58-3
2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3,3-difluoro-3-(N-methylcarbamoyl)-2-oxopropyl]acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / aq. K₂CO₃ / tetrahydrofuran; methanol / 20 °C

2: 39 percent / N-ethylmorpholine; 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride; 3-hydroxybenzotriazole hydrate / dimethylformamide / 18 h / 20 °C

3: 100 percent / H₂; 1 N aq. HCl / 10percent Pd/C / methanol / 15 h / 20 °C

4: 82 percent / N-ethylmorpholine; 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride; 3-hydroxybenzotriazole hydrate / dimethylformamide / 16 h / 20 °C

5: 69 percent / Dess-Martin periodinate / dimethylformamide / 14 h / 20 °C

With N-ethylmorpholine;; hydrogenchloride; hydrogen; potassium carbonate; Dess-Martin periodane; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 10percent Pd/C; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 5: Dess-Martin oxidation;
DOI:10.1021/jm000497n

Reference yield:

: 339169-54-9
4-benzyl-4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-N-methylbutanamide

: 339169-58-3
2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3,3-difluoro-3-(N-methylcarbamoyl)-2-oxopropyl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / H₂; 1 N aq. HCl / 10percent Pd/C / methanol / 15 h / 20 °C

2: 82 percent / N-ethylmorpholine; 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride; 3-hydroxybenzotriazole hydrate / dimethylformamide / 16 h / 20 °C

3: 69 percent / Dess-Martin periodinate / dimethylformamide / 14 h / 20 °C

With N-ethylmorpholine;; hydrogenchloride; hydrogen; Dess-Martin periodane; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 10percent Pd/C; In methanol; N,N-dimethyl-formamide; 3: Dess-Martin oxidation;
DOI:10.1021/jm000497n