4-benzyl-4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-N-methylbutanamide

Base Information

Chemical Name:4-benzyl-4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-N-methylbutanamide
CAS No.:339169-54-9
Molecular Formula:C₂₀H₂₂F₂N₂O₄
Molecular Weight:392.402
Hs Code.:

Synonyms:4-benzyl-4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-N-methylbutanamide

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Chemical Property of 4-benzyl-4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-N-methylbutanamide

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Technology Process of 4-benzyl-4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-N-methylbutanamide

There total 2 articles about 4-benzyl-4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-N-methylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 593-51-1
methylamine hydrochloride

: 4-benzyl-4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxybutanoic acid

: 339169-54-9
4-benzyl-4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-N-methylbutanamide

Guidance literature:: With N-ethylmorpholine;; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/jm000497n

Reference yield:

: 59830-60-3,63219-70-5,68474-26-0
N-benzyloxycarbonyl-2-amino-3-phenylpropionaldehyde

: 339169-54-9
4-benzyl-4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-N-methylbutanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / aq. K₂CO₃ / tetrahydrofuran; methanol / 20 °C

2: 39 percent / N-ethylmorpholine; 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride; 3-hydroxybenzotriazole hydrate / dimethylformamide / 18 h / 20 °C

With N-ethylmorpholine;; potassium carbonate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm000497n