(2S)-2-amino-3-(3,4-bis((2-(benzoyloxy)-2-methylpropanoyl)oxy)phenyl)propanoic acid tosylate

Base Information

Chemical Name:(2S)-2-amino-3-(3,4-bis((2-(benzoyloxy)-2-methylpropanoyl)oxy)phenyl)propanoic acid tosylate
CAS No.:1379614-09-1
Molecular Formula:C₇H₈O₃S*C₃₁H₃₁NO₁₀
Molecular Weight:749.793
Hs Code.:

Synonyms:(2S)-2-amino-3-(3,4-bis((2-(benzoyloxy)-2-methylpropanoyl)oxy)phenyl)propanoic acid tosylate

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Chemical Property of (2S)-2-amino-3-(3,4-bis((2-(benzoyloxy)-2-methylpropanoyl)oxy)phenyl)propanoic acid tosylate

Chemical Property:

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Technology Process of (2S)-2-amino-3-(3,4-bis((2-(benzoyloxy)-2-methylpropanoyl)oxy)phenyl)propanoic acid tosylate

There total 8 articles about (2S)-2-amino-3-(3,4-bis((2-(benzoyloxy)-2-methylpropanoyl)oxy)phenyl)propanoic acid tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1379613-67-8
(2S)-3-((3,4-bis((2-benzoyloxy)-2-methylpropanoyl)oxy)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid

: 104-15-4
toluene-4-sulfonic acid

: 1379614-09-1
(2S)-2-amino-3-(3,4-bis((2-(benzoyloxy)-2-methylpropanoyl)oxy)phenyl)propanoic acid tosylate

Guidance literature:: In acetonitrile; at 70 ℃; for 2h;

Reference yield:

: 59-92-7,90638-38-3
levodopa

: 1379614-09-1
(2S)-2-amino-3-(3,4-bis((2-(benzoyloxy)-2-methylpropanoyl)oxy)phenyl)propanoic acid tosylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / water; tetrahydrofuran / 14 h / 20 °C / Inert atmosphere

1.2: Cooling with ice

2.1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 7 h / 20 °C / Inert atmosphere

3.1: triethylamine / acetonitrile / 1.25 h / Cooling with ice; Inert atmosphere

4.1: hydrogen; palladium 10% on activated carbon / ethanol / 2 h / 20 °C / Inert atmosphere

5.1: acetonitrile / 2 h / 70 °C

With palladium 10% on activated carbon; hydrogen; potassium hydrogencarbonate; triethylamine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 58570-00-6
2-(benzoyloxy)-2-methylpropanoic acid

: 1379614-09-1
(2S)-2-amino-3-(3,4-bis((2-(benzoyloxy)-2-methylpropanoyl)oxy)phenyl)propanoic acid tosylate

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide; thionyl chloride / toluene / 1 h / 70 °C / Inert atmosphere

2: triethylamine / acetonitrile / 1.25 h / Cooling with ice; Inert atmosphere

3: hydrogen; palladium 10% on activated carbon / ethanol / 2 h / 20 °C / Inert atmosphere

4: acetonitrile / 2 h / 70 °C

With thionyl chloride; palladium 10% on activated carbon; hydrogen; triethylamine; N,N-dimethyl-formamide; In ethanol; toluene; acetonitrile;