1,1-dimethylethyl ((1R)-1-methyl-1-{[(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)amino]carbonyl}propyl)carbamate

Base Information

Chemical Name:1,1-dimethylethyl ((1R)-1-methyl-1-{[(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)amino]carbonyl}propyl)carbamate
CAS No.:1311138-52-9
Molecular Formula:C₂₃H₃₁N₃O₅
Molecular Weight:429.516
Hs Code.:

Synonyms:1,1-dimethylethyl ((1R)-1-methyl-1-{[(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)amino]carbonyl}propyl)carbamate

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Chemical Property of 1,1-dimethylethyl ((1R)-1-methyl-1-{[(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)amino]carbonyl}propyl)carbamate

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Technology Process of 1,1-dimethylethyl ((1R)-1-methyl-1-{[(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)amino]carbonyl}propyl)carbamate

There total 6 articles about 1,1-dimethylethyl ((1R)-1-methyl-1-{[(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)amino]carbonyl}propyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1311138-07-4
6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinamine

: 123254-58-0
(R)-2-((tert-butoxycarbonyl)amino)-2-methylbutanoic acid

: 1311138-52-9
1,1-dimethylethyl ((1R)-1-methyl-1-{[(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)amino]carbonyl}propyl)carbamate

Guidance literature:: (R)-2-((tert-butoxycarbonyl)amino)-2-methylbutanoic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 1311138-07-4
6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinamine

: 151171-11-8
(S)-2-((tert-butoxycarbonyl)amino)-2-methylbutanoic acid

: 1311138-52-9
1,1-dimethylethyl ((1R)-1-methyl-1-{[(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)amino]carbonyl}propyl)carbamate

Guidance literature:: (S)-2-((tert-butoxycarbonyl)amino)-2-methylbutanoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinamine; In N,N-dimethyl-formamide; at 20 - 50 ℃;

Reference yield:

: 19217-50-6
4-methyl-3-(methyloxy)phenol

: 1311138-52-9
1,1-dimethylethyl ((1R)-1-methyl-1-{[(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)amino]carbonyl}propyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 115 °C

2.1: water; ammonium chloride / iron / tetrahydrofuran / 8 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C

3.2: 20 - 50 °C

With water; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; HATU; iron; In tetrahydrofuran; N,N-dimethyl-formamide;