(2R,3S)-2-(tert-butyldiphenyl silyloxy)methyl-3-hydroxy-1-p-methoxyphenyl-azetidine

Base Information

Chemical Name:(2R,3S)-2-(tert-butyldiphenyl silyloxy)methyl-3-hydroxy-1-p-methoxyphenyl-azetidine
CAS No.:150456-19-2
Molecular Formula:C₂₇H₃₃NO₃Si
Molecular Weight:447.649
Hs Code.:

Synonyms:(2R,3S)-2-(tert-butyldiphenyl silyloxy)methyl-3-hydroxy-1-p-methoxyphenyl-azetidine

Suppliers and Price of (2R,3S)-2-(tert-butyldiphenyl silyloxy)methyl-3-hydroxy-1-p-methoxyphenyl-azetidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (2R,3S)-2-(tert-butyldiphenyl silyloxy)methyl-3-hydroxy-1-p-methoxyphenyl-azetidine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of (2R,3S)-2-(tert-butyldiphenyl silyloxy)methyl-3-hydroxy-1-p-methoxyphenyl-azetidine

There total 4 articles about (2R,3S)-2-(tert-butyldiphenyl silyloxy)methyl-3-hydroxy-1-p-methoxyphenyl-azetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 150456-18-1
(2R,3S)-3-benzyloxy-2-(tert-butyldiphenyl silyloxy)methyl-1-p-methoxyphenyl-azetidine

: 150456-19-2
(2R,3S)-2-(tert-butyldiphenyl silyloxy)methyl-3-hydroxy-1-p-methoxyphenyl-azetidine

Guidance literature:: With cyclohexene; palladium hydroxide - carbon; In ethanol; for 20h; Heating;
DOI:10.1016/S0040-4020(01)85738-0

Reference yield:

: 150456-08-9
2-O-benzyl-4-O-tert-butyldiphenylsilyl-L-threitol

: 150456-19-2
(2R,3S)-2-(tert-butyldiphenyl silyloxy)methyl-3-hydroxy-1-p-methoxyphenyl-azetidine

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / Et₃N, DMAP / CH₂Cl₂ / 2 h / Ambient temperature

2: 70 percent / toluene / 48 h / Heating

3: 65 percent / cyclohexene / 20percent palladium hydroxide/C / ethanol / 20 h / Heating

With dmap; triethylamine; cyclohexene; palladium hydroxide - carbon; In ethanol; dichloromethane; toluene;
DOI:10.1016/S0040-4020(01)85738-0

Reference yield:

: 2-O-benzyl-1,3-O-benzylidene-4-O-tert-butyldiphenylsilyl-L-threitol

: 150456-19-2
(2R,3S)-2-(tert-butyldiphenyl silyloxy)methyl-3-hydroxy-1-p-methoxyphenyl-azetidine

Guidance literature:: Multi-step reaction with 4 steps

1: CH₃COOH, H₂O / 15 h / 40 °C

2: 92 percent / Et₃N, DMAP / CH₂Cl₂ / 2 h / Ambient temperature

3: 70 percent / toluene / 48 h / Heating

4: 65 percent / cyclohexene / 20percent palladium hydroxide/C / ethanol / 20 h / Heating

With dmap; water; acetic acid; triethylamine; cyclohexene; palladium hydroxide - carbon; In ethanol; dichloromethane; toluene;
DOI:10.1016/S0040-4020(01)85738-0