(2R,3S)-3-benzyloxy-2-(tert-butyldiphenyl silyloxy)methyl-1-p-methoxyphenyl-azetidine

Base Information

Chemical Name:(2R,3S)-3-benzyloxy-2-(tert-butyldiphenyl silyloxy)methyl-1-p-methoxyphenyl-azetidine
CAS No.:150456-18-1
Molecular Formula:C₃₄H₃₉NO₃Si
Molecular Weight:537.774
Hs Code.:

Synonyms:(2R,3S)-3-benzyloxy-2-(tert-butyldiphenyl silyloxy)methyl-1-p-methoxyphenyl-azetidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S)-3-benzyloxy-2-(tert-butyldiphenyl silyloxy)methyl-1-p-methoxyphenyl-azetidine

Chemical Property:

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Technology Process of (2R,3S)-3-benzyloxy-2-(tert-butyldiphenyl silyloxy)methyl-1-p-methoxyphenyl-azetidine

There total 5 articles about (2R,3S)-3-benzyloxy-2-(tert-butyldiphenyl silyloxy)methyl-1-p-methoxyphenyl-azetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 104-94-9
4-methoxy-aniline

: 150456-09-0
2-O-benzyl-4-O-tert-butyldiphenylsilyl-1,3-di-O-methylsufonyl-L-threitol

: 150456-18-1
(2R,3S)-3-benzyloxy-2-(tert-butyldiphenyl silyloxy)methyl-1-p-methoxyphenyl-azetidine

Guidance literature:: In toluene; for 48h; Heating;
DOI:10.1016/S0040-4020(01)85738-0

Reference yield:

: 84379-51-1,84379-52-2,124909-02-0,127000-44-6
2-O-benzyl-L-threitol

: 150456-18-1
(2R,3S)-3-benzyloxy-2-(tert-butyldiphenyl silyloxy)methyl-1-p-methoxyphenyl-azetidine

Guidance literature:: Multi-step reaction with 5 steps

1: 65 percent / CF₃COOH / CH₂Cl₂ / 15 h / Heating

2: 90 percent / imidazole / dimethylformamide / 2 h / Ambient temperature

3: CH₃COOH, H₂O / 15 h / 40 °C

4: 92 percent / Et₃N, DMAP / CH₂Cl₂ / 2 h / Ambient temperature

5: 70 percent / toluene / 48 h / Heating

With 1H-imidazole; dmap; water; acetic acid; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(01)85738-0

Reference yield:

: 107938-31-8
(2S,3S)-1,3-O-Benzylidene-2-O-benzylthreitol

: 150456-18-1
(2R,3S)-3-benzyloxy-2-(tert-butyldiphenyl silyloxy)methyl-1-p-methoxyphenyl-azetidine

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / imidazole / dimethylformamide / 2 h / Ambient temperature

2: CH₃COOH, H₂O / 15 h / 40 °C

3: 92 percent / Et₃N, DMAP / CH₂Cl₂ / 2 h / Ambient temperature

4: 70 percent / toluene / 48 h / Heating

With 1H-imidazole; dmap; water; acetic acid; triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(01)85738-0