1-Benzoyl-3-[2-(2-tert-butyl-phenoxy)-pyridin-3-yl]-thiourea

Base Information

• Chemical Name: 1-Benzoyl-3-[2-(2-tert-butyl-phenoxy)-pyridin-3-yl]-thiourea
• CAS No.: 870552-37-7
• Molecular Formula: C₂₃H₂₃N₃O₂S
• Molecular Weight: 405.521
• Mol file: 870552-37-7.mol

Synonyms:1-Benzoyl-3-[2-(2-tert-butyl-phenoxy)-pyridin-3-yl]-thiourea

Chemical Property of 1-Benzoyl-3-[2-(2-tert-butyl-phenoxy)-pyridin-3-yl]-thiourea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Benzoyl-3-[2-(2-tert-butyl-phenoxy)-pyridin-3-yl]-thiourea

There total 4 articles about 1-Benzoyl-3-[2-(2-tert-butyl-phenoxy)-pyridin-3-yl]-thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-(2-(tert-butyl)phenoxy)pyridin-3-amine (861673-68-9) + Benzoyl isothiocyanate (532-55-8) → 1-Benzoyl-3-[2-(2-tert-butyl-phenoxy)-pyridin-3-yl]-thiourea (870552-37-7)

Guidance literature:

In dichloromethane; at 50 ℃; for 2h;

DOI:10.1016/j.bmcl.2013.05.025

Reference yield:

2-fluoro-3-nitropyridine (1480-87-1) → 1-Benzoyl-3-[2-(2-tert-butyl-phenoxy)-pyridin-3-yl]-thiourea (870552-37-7)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 144 h / 130 °C

2: palladium 10% on activated carbon; hydrogen / methanol; tetrahydrofuran

3: dichloromethane / 2 h / 50 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2013.05.025

Reference yield:

2-tert-Butylphenol (88-18-6) → 1-Benzoyl-3-[2-(2-tert-butyl-phenoxy)-pyridin-3-yl]-thiourea (870552-37-7)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 144 h / 130 °C

2: palladium 10% on activated carbon; hydrogen / methanol; tetrahydrofuran

3: dichloromethane / 2 h / 50 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2013.05.025

upstream raw materials:

2-(2-(tert-butyl)phenoxy)pyridin-3-amine

Benzoyl isothiocyanate

2-fluoro-3-nitropyridine

2-tert-Butylphenol

Downstream raw materials:

C₂₄H₂₃N₃OS

C₂₅H₃₁N₃O₃S

C₂₅H₃₀BrN₃O₃S

C₃₁H₃₅N₃O₃S