2-[(3-chlorophenyl)-(2-methoxyphenoxy)-methyl]morpholine-4-carboxylic acid tert-butyl ester

Base Information

Chemical Name:2-[(3-chlorophenyl)-(2-methoxyphenoxy)-methyl]morpholine-4-carboxylic acid tert-butyl ester
CAS No.:863969-90-8
Molecular Formula:C₂₃H₂₈ClNO₅
Molecular Weight:433.932
Hs Code.:

Synonyms:2-[(3-chlorophenyl)-(2-methoxyphenoxy)-methyl]morpholine-4-carboxylic acid tert-butyl ester

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Chemical Property of 2-[(3-chlorophenyl)-(2-methoxyphenoxy)-methyl]morpholine-4-carboxylic acid tert-butyl ester

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Technology Process of 2-[(3-chlorophenyl)-(2-methoxyphenoxy)-methyl]morpholine-4-carboxylic acid tert-butyl ester

There total 10 articles about 2-[(3-chlorophenyl)-(2-methoxyphenoxy)-methyl]morpholine-4-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 863969-89-5
[3-(3-chlorophenyl)-2-hydroxy-3-(2-methoxyphenoxy)propyl]-(2-hydroxyethyl)carbamic acid tert-butyl ester

: 863969-90-8
2-[(3-chlorophenyl)-(2-methoxyphenoxy)-methyl]morpholine-4-carboxylic acid tert-butyl ester

Guidance literature:: [3-(3-chlorophenyl)-2-hydroxy-3-(2-methoxyphenoxy)propyl]-(2-hydroxyethyl)carbamic acid tert-butyl ester; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 1.08333h;

With N-tosylimidazole; In tetrahydrofuran; at 20 ℃; for 19h;
DOI:10.1016/j.tetasy.2005.06.012

Reference yield:

: 125617-30-3
rac-(3-(3-chlorophenyl)oxiran-2-yl)methanol

: 863969-90-8
2-[(3-chlorophenyl)-(2-methoxyphenoxy)-methyl]morpholine-4-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: aq. NaOH; methyltributylammonium chloride / CH₂Cl₂ / 2 h / 20 °C

1.2: 39 percent / 3 h / 65 °C

2.1: Et₃N / ethyl acetate / 0.25 h / -20 °C

3.1: Et₃N / ethyl acetate / 0.25 h / -20 °C

4.1: aq. HCl / ethyl acetate / -20 - 20 °C

5.1: aq. NaOH; methyltributylammonium chloride / toluene / 20 °C

6.1: 48 percent / propan-2-ol / Heating

7.1: 92 percent / CH₂Cl₂ / 1 h / 20 °C

8.1: NaH / tetrahydrofuran / 1.08 h / 0 - 20 °C

8.2: 60 percent / 1-(p-toluenesulfonyl)imidazole / tetrahydrofuran / 19 h / 20 °C

With hydrogenchloride; sodium hydroxide; sodium hydride; triethylamine; methyl tributylammonium chloride; In tetrahydrofuran; dichloromethane; ethyl acetate; isopropyl alcohol; toluene;
DOI:10.1016/j.tetasy.2005.06.012

Reference yield:

: 863969-83-9
1,2-epoxy-3-[(3-chlorophenyl)-(2-methoxyphenoxy)]propane

: 863969-90-8
2-[(3-chlorophenyl)-(2-methoxyphenoxy)-methyl]morpholine-4-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 48 percent / propan-2-ol / Heating

2.1: 92 percent / CH₂Cl₂ / 1 h / 20 °C

3.1: NaH / tetrahydrofuran / 1.08 h / 0 - 20 °C

3.2: 60 percent / 1-(p-toluenesulfonyl)imidazole / tetrahydrofuran / 19 h / 20 °C

With sodium hydride; In tetrahydrofuran; dichloromethane; isopropyl alcohol;
DOI:10.1016/j.tetasy.2005.06.012