125617-30-3

Upstream product

• 770-23-0 (E)-3-(3-chlorophenyl)propenal 
• 1504-67-2 3-(3-chlorophenyl)prop-2-en-1-ol 
• 2373-88-8 ethyl (E)-3-(3-chlorophenyl)prop-2-enoate 
• 119125-31-4 (E)-3-(3-chlorophenyl)prop-2-en-1-ol 

Downstream Products

• 632327-18-5 (R)-(+)-1-(3-chlorophenyl)-1,3-propanediol 
• 71621-61-9 2-[(3-chlorophenyl)-(2-methoxyphenoxy)-methyl]morpholine 
• 863969-86-2 4-nitro-benzenesulfonic acid 2-[[3-(3-chloro-phenyl)-2-hydroxy-3-(2-methoxy-phenoxy)-propyl]-(4-nitro-benzenesulfonyl)-amino]-ethyl ester 
• 863969-85-1 toluene-4-sulfonic acid 2-[[3-(3-chloro-phenyl)-2-hydroxy-3-(2-methoxy-phenoxy)-propyl]-(toluene-4-sulfonyl)-amino]-ethyl ester 
• 863969-89-5 [3-(3-chlorophenyl)-2-hydroxy-3-(2-methoxyphenoxy)propyl]-(2-hydroxyethyl)carbamic acid tert-butyl ester 
• 863969-90-8 2-[(3-chlorophenyl)-(2-methoxyphenoxy)-methyl]morpholine-4-carboxylic acid tert-butyl ester 
• 863969-84-0 [3-(3-chlorophenyl)-2-hydroxy-3-(2-methoxyphenoxy)]-(1-hydroxyethylamino)propane 
• 863969-83-9 1,2-epoxy-3-[(3-chlorophenyl)-(2-methoxyphenoxy)]propane 
• 863969-82-8 3-(3-chlorophenyl)-3-(2-methoxyphenoxy)-propane-1,2-diol 

Relevant academic research and scientific papers

Enantiocomplementary Epoxidation Reactions Catalyzed by an Engineered Cofactor-Independent Non-natural Peroxygenase

Peroxygenases are heme-dependent enzymes that use peroxide-borne oxygen to catalyze a wide range of oxyfunctionalization reactions. Herein, we report the engineering of an unusual cofactor-independent peroxygenase based on a promiscuous tautomerase that accepts different hydroperoxides (t-BuOOH and H2O2) to accomplish enantiocomplementary epoxidations of various α,β-unsaturated aldehydes (citral and substituted cinnamaldehydes), providing access to both enantiomers of the corresponding α,β-epoxy-aldehydes. High conversions (up to 98 %), high enantioselectivity (up to 98 % ee), and good product yields (50–80 %) were achieved. The reactions likely proceed via a reactive enzyme-bound iminium ion intermediate, allowing tweaking of the enzyme's activity and selectivity by protein engineering. Our results underscore the potential of catalytic promiscuity for the engineering of new cofactor-independent oxidative enzymes.

NOVEL 2'-C-METHYL AND 4'-C-METHYL NUCLEOSIDE DERIVATIVES

Novel 2'-C-methyl nucleoside 5 '-monophosphate and 4'-C-methyl nucleoside 5'- monophosphate derivatives, stereoisomers, and pharmaceutically acceptable salts or prodrugs thereof, their preparation, and their uses for the treatment of hepatitis C viral inf

Enantioselective synthesis of (2R,3R)- and (2S,3S)-2-[(3-chlorophenyl)-(2- methoxyphenoxy)methyl]morpholine

The enantioselective synthesis of the (R,R)- and (S,S)-enantiomers of 1 from commercially available 3-chlorocinnamic acid is reported. The Sharpless asymmetric epoxidation was used to establish the stereocenters in the synthesis of both enantiomers of 1.

Novel 2'-C-methyl nucleoside derivatives

Compounds of Formula I, stereoisomers, and pharmaceutically acceptable salts or prodrugs thereof, their preparation, and their uses for the treatment of hepatitis C viral infection are described:

Novel phosphonic acid based prodrugs of PMEA and its analogues

Prodrugs of Formula I, their uses, their intermediates, and their method of manufacture are described: 1wherein: M and V are cis to one another and MPO3H2 is a phosphonic acid selected from the group consisting of 9-(2-phosphonylmet