3-iodo-1-methoxymethyl-1H-indole-2-carboxylic acid allyl-phenyl-amide

Base Information

• Chemical Name: 3-iodo-1-methoxymethyl-1H-indole-2-carboxylic acid allyl-phenyl-amide
• CAS No.: 482370-91-2
• Molecular Formula: C₂₀H₁₉IN₂O₂
• Molecular Weight: 446.288
• Mol file: 482370-91-2.mol

Synonyms:3-iodo-1-methoxymethyl-1H-indole-2-carboxylic acid allyl-phenyl-amide

Chemical Property of 3-iodo-1-methoxymethyl-1H-indole-2-carboxylic acid allyl-phenyl-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-iodo-1-methoxymethyl-1H-indole-2-carboxylic acid allyl-phenyl-amide

There total 4 articles about 3-iodo-1-methoxymethyl-1H-indole-2-carboxylic acid allyl-phenyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 3-iodo-1H-indole-2-carboxylate (117637-79-3) → 3-iodo-1-methoxymethyl-1H-indole-2-carboxylic acid allyl-phenyl-amide (482370-91-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: NaH / tetrahydrofuran / 0.25 h

1.2: 1.55 g / tetrahydrofuran / 1.5 h / 35 - 40 °C

2.1: 91 percent / KOH / H₂O; methanol / 0.5 h / Heating

3.1: oxalyl chloride / tetrahydrofuran; dimethylformamide / 1 h / Heating

4.1: 422 mg / CH₂Cl₂ / 1 h / 20 °C

With potassium hydroxide; oxalyl dichloride; sodium hydride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(02)00688-9

Reference yield:

3-iodo-1-methoxymethyl-1H-indole-2-carboxylic acid (482370-81-0) → 3-iodo-1-methoxymethyl-1H-indole-2-carboxylic acid allyl-phenyl-amide (482370-91-2)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride / tetrahydrofuran; dimethylformamide / 1 h / Heating

2: 422 mg / CH₂Cl₂ / 1 h / 20 °C

With oxalyl dichloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(02)00688-9

Reference yield:

3-iodo-1-methoxymethyl-1H-indole-2-carboxylic acid ethyl ester (482370-80-9) → 3-iodo-1-methoxymethyl-1H-indole-2-carboxylic acid allyl-phenyl-amide (482370-91-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / KOH / H₂O; methanol / 0.5 h / Heating

2: oxalyl chloride / tetrahydrofuran; dimethylformamide / 1 h / Heating

3: 422 mg / CH₂Cl₂ / 1 h / 20 °C

With potassium hydroxide; oxalyl dichloride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(02)00688-9

upstream raw materials:

N-allyl-N-phenylamine

ethyl 3-iodo-1H-indole-2-carboxylate

3-iodo-1-methoxymethyl-1H-indole-2-carboxylic acid

3-iodo-1-methoxymethyl-1H-indole-2-carboxylic acid ethyl ester