Welcome to LookChem.com Sign In|Join Free
  • or

Encyclopedia

(3R,4S)-4-(4-(Benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)azetidin-2-one

Base Information Edit
  • Chemical Name:(3R,4S)-4-(4-(Benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)azetidin-2-one
  • CAS No.:163222-32-0
  • Molecular Formula:C31H27F2NO3
  • Molecular Weight:499.557
  • Hs Code.:
  • DSSTox Substance ID:DTXSID101107850
  • Nikkaji Number:J1.125.961H
  • Wikidata:Q76415814
  • ChEMBL ID:CHEMBL173660
  • Mol file:163222-32-0.mol
(3R,4S)-4-(4-(Benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)azetidin-2-one

Synonyms:163222-32-0;4'-O-Benzyloxy Ezetimibe;(3R,4S)-4-(4-(Benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)azetidin-2-one;(3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-phenylmethoxyphenyl)azetidin-2-one;(3R,4S)-1-(4-FLUOROPHENYL)-3-[(3S)-3-(4-FLUOROPHENYL)-3-HYDROXYPROPYL]-4-[4-(PHENYLMETHOXY)PHENYL]-2-AZETIDINONE;1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-[4-(phenylmethoxy)phenyl]-, (3R,4S)- 2-Azetidinone;4'-O-Benzyl Ezetimibe;2-AZETIDINONE, 1-(4-FLUOROPHENYL)-3-[(3S)-3-(4-FLUOROPHENYL)-3-HYDROXYPROPYL]-4-[4-(PHENYLMETHOXY)PHENYL]-, (3R,4S)-;(3R,4S)-4-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]azetidin-2-one;Ezetimibe Intermediate-L;CHEMBL173660;SCHEMBL2046587;C31H27F2NO3;DTXSID101107850;AMY19257;C31 H27 F2 N O3;MFCD00937870;AKOS024464695;AC-8741;CS-T-05991;DS-9698;2-Azetidinone,1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-[4-(phenylmethoxy)phenyl]-, (3R,4S)-;CS-0140352;C73140;(3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3(s)-hydroxypropyl]-4-(4-benzyloxyphenyl)-2-azetidinone;(3R,4S)-4-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]azetidin-2-one;1-(4-fluorophenyl)-3(R)-(3(S)-(4-fluorophenyl)-3-hydroxypropyl)-4(S)-(4-benzyloxyphenyl)-2-azetidinone;1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-[4-(phenylmethoxy)phenyl]-(3R,4S)-2-azetidinone;1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-[4-(phenylmethoxy)phenyl]-,(3R,4S)- 2-Azetidinone;1-(4-Fluorophenyl)-3alpha-[(S)-3-hydroxy-3-(4-fluorophenyl)propyl]-4beta-[4-(benzyloxy)phenyl]azetidine-2-one;2-azetidinona, 1-(4-fluorofenil)-3-[(3s)-3-(4-fluorofenil)-3-hidroxipropil]-4-[4-(fenilmetoxi)fenil]-, (3r,4s)-;2-Azetidinone,1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-[4-(phenylmethoxy)phenyl]-,(3R,4S)-;4(S)-(4-Benzyloxyphenyl)-1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-azetidine-2-one

Suppliers and Price of (3R,4S)-4-(4-(Benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)azetidin-2-one
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • 4’-O-BenzyloxyEzetimibe
  • 5 mg
  • $ 145.00
  • Crysdot
  • (3R,4S)-4-(4-(Benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)azetidin-2-one 95+%
  • 10g
  • $ 287.00
  • Crysdot
  • (3R,4S)-4-(4-(Benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)azetidin-2-one 95+%
  • 25g
  • $ 574.00
  • Chemenu
  • (3R,4S)-4-(4-(Benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)azetidin-2-one 95%
  • 25g
  • $ 542.00
  • Chemenu
  • (3R,4S)-4-(4-(Benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)azetidin-2-one 95%
  • 10g
  • $ 271.00
  • Chemenu
  • (3R,4S)-4-(4-(Benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)azetidin-2-one 95%
  • 5g
  • $ 184.00
  • Biosynth Carbosynth
  • 4'-O-Benzyloxy ezetimibe
  • 100 mg
  • $ 100.00
  • Biosynth Carbosynth
  • 4'-O-Benzyloxy ezetimibe
  • 250 mg
  • $ 150.00
  • Biosynth Carbosynth
  • 4'-O-Benzyloxy ezetimibe
  • 500 mg
  • $ 250.00
  • Biosynth Carbosynth
  • 4'-O-Benzyloxy ezetimibe
  • 2 g
  • $ 450.00
Total 84 raw suppliers
Chemical Property of (3R,4S)-4-(4-(Benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)azetidin-2-one Edit
Chemical Property:
  • Appearance/Colour:Off-white solid 
  • Vapor Pressure:0mmHg at 25°C 
  • Refractive Index:1.617 
  • Boiling Point:706.462 °C at 760 mmHg 
  • PKA:14.15±0.20(Predicted) 
  • Flash Point:381.055 °C 
  • PSA:49.77000 
  • Density:1.271 g/cm3 
  • LogP:6.82670 
  • Storage Temp.:Sealed in dry,Room Temperature 
  • Solubility.:DMSO (Slightly), Methanol (Slightly, Heated) 
  • XLogP3:5.8
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:5
  • Rotatable Bond Count:9
  • Exact Mass:499.19590005
  • Heavy Atom Count:37
  • Complexity:707
Purity/Quality:

≥98.0% *data from raw suppliers

4’-O-BenzyloxyEzetimibe *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:C1=CC=C(C=C1)COC2=CC=C(C=C2)C3C(C(=O)N3C4=CC=C(C=C4)F)CCC(C5=CC=C(C=C5)F)O
  • Isomeric SMILES:C1=CC=C(C=C1)COC2=CC=C(C=C2)[C@@H]3[C@H](C(=O)N3C4=CC=C(C=C4)F)CC[C@@H](C5=CC=C(C=C5)F)O
  • Uses (3R,4S)-4-(4-(Benzyloxy)Phenyl)-1-(4-Fluorophenyl)-3-((S)-3-(4-Fluorophenyl)-3-Hydroxypropyl)Azetidin-2-One is protected Ezetimibe, used for the synthesis of related derivatives.
Technology Process of (3R,4S)-4-(4-(Benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)azetidin-2-one

There total 62 articles about (3R,4S)-4-(4-(Benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With formic acid; [(S,S)-teth-TsDpen RuCl]; triethylamine; In ethylbenzene; at 35 - 40 ℃; for 24h; Inert atmosphere;
Guidance literature:
4-flourophenylmagnesium bromide; With (R)-1,1'-Bi-2-naphthol; titanium(IV) isopropylate; In tetrahydrofuran; diethyl ether; at 0 - 25 ℃; for 1.5h;
3-[(2S,3R)-2-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-4-oxoazetidin-3-yl]propanal; In tetrahydrofuran; diethyl ether; at -20 - 25 ℃;
With hydrogenchloride; water; In tetrahydrofuran; diethyl ether; at 0 ℃;
Post RFQ for Price