6-(4-fluorophenyl)-5-[4-(2-piperidin-1-ylethoxy)phenoxy]naphthalen-2-ol

Base Information

• Chemical Name: 6-(4-fluorophenyl)-5-[4-(2-piperidin-1-ylethoxy)phenoxy]naphthalen-2-ol
• CAS No.: 861930-46-3
• Molecular Formula: C₂₉H₂₈FNO₃
• Molecular Weight: 457.545
• Mol file: 861930-46-3.mol

Synonyms:6-(4-fluorophenyl)-5-[4-(2-piperidin-1-ylethoxy)phenoxy]naphthalen-2-ol

Chemical Property of 6-(4-fluorophenyl)-5-[4-(2-piperidin-1-ylethoxy)phenoxy]naphthalen-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(4-fluorophenyl)-5-[4-(2-piperidin-1-ylethoxy)phenoxy]naphthalen-2-ol

There total 9 articles about 6-(4-fluorophenyl)-5-[4-(2-piperidin-1-ylethoxy)phenoxy]naphthalen-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1-(2-{4-[2-(4-fluorophenyl)-6-methoxynaphthalen-1-yloxy]phenoxy}ethyl)piperidine hydrochloride → 6-(4-fluorophenyl)-5-[4-(2-piperidin-1-ylethoxy)phenoxy]naphthalen-2-ol (861930-46-3)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 2h;

DOI:10.1021/jm050723z

Reference yield: 54.0%

1-(2-{4-[6-benzyloxy-2-(4-fluoro-phenyl)-naphthalen-1-yloxy]-phenoxy}-ethyl)-piperidine → 6-(4-fluorophenyl)-5-[4-(2-piperidin-1-ylethoxy)phenoxy]naphthalen-2-ol (861930-46-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; for 2h;

Reference yield:

2-(benzyloxy)-1-bromo-6-methoxynaphthalene (648904-47-6) → 6-(4-fluorophenyl)-5-[4-(2-piperidin-1-ylethoxy)phenoxy]naphthalen-2-ol (861930-46-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 30 percent / copper triflate

2: NH₄HCO₂ / Pd(OH)2

3: PCy₃; CsF / Pd(OAc)2

4: BBr₃

With ammonium formate; boron tribromide; copper(I) triflate; cesium fluoride; tricyclohexylphosphine; palladium diacetate; palladium dihydroxide; 1: Ullman coupling / 4: Suzuki coupling;

DOI:10.1016/j.bmcl.2007.04.044

upstream raw materials:

2-(benzyloxy)-1-bromo-6-methoxynaphthalene

6-methoxy-1-[4-(2-piperidin-1-ylethoxy)phenoxy]naphthalene-2-ol

1-{2-[4-(2-benzyloxy-6-methoxynaphthalen-1-yloxy)phenoxy]ethyl}piperidine

trifluoromethanesulfonic acid 6-methoxy-1-[4-(2-piperidin-1-ylethoxy)phenoxy]naphthalen-2-yl ester