3,5-bis[(4-methoxyphenyl)hydroxymethyl]anisole

Base Information

• Chemical Name: 3,5-bis[(4-methoxyphenyl)hydroxymethyl]anisole
• CAS No.: 1415037-91-0
• Molecular Formula: C₂₃H₂₄O₅
• Molecular Weight: 380.441
• Mol file: 1415037-91-0.mol

Synonyms:3,5-bis[(4-methoxyphenyl)hydroxymethyl]anisole

Chemical Property of 3,5-bis[(4-methoxyphenyl)hydroxymethyl]anisole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-bis[(4-methoxyphenyl)hydroxymethyl]anisole

There total 5 articles about 3,5-bis[(4-methoxyphenyl)hydroxymethyl]anisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

3,5-bis(4-methoxybenzoyl)anisole (1415037-90-9) → 3,5-bis[(4-methoxyphenyl)hydroxymethyl]anisole (1415037-91-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 4h; Cooling with ice;

DOI:10.1021/ma302300g

Reference yield:

5-Hydroxyisophthalic acid (618-83-7) → 3,5-bis[(4-methoxyphenyl)hydroxymethyl]anisole (1415037-91-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium carbonate / acetone / Reflux

2.1: potassium hydroxide; water / methanol / 6 h / Reflux

2.2: 20 °C / pH 3

3.1: thionyl chloride / 5 h / Reflux

4.1: aluminum (III) chloride / carbon disulfide / 3.5 h / Cooling with ice

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 20 °C / Cooling with ice

With aluminum (III) chloride; lithium aluminium tetrahydride; thionyl chloride; water; potassium carbonate; potassium hydroxide; In tetrahydrofuran; methanol; carbon disulfide; acetone; 4.1: |Friedel-Crafts Acylation;

DOI:10.1021/ma302300g

Reference yield:

dimethyl 5-methoxyisophthalate (20319-44-2) → 3,5-bis[(4-methoxyphenyl)hydroxymethyl]anisole (1415037-91-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium hydroxide; water / methanol / 6 h / Reflux

1.2: 20 °C / pH 3

2.1: thionyl chloride / 5 h / Reflux

3.1: aluminum (III) chloride / carbon disulfide / 3.5 h / Cooling with ice

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 20 °C / Cooling with ice

With aluminum (III) chloride; lithium aluminium tetrahydride; thionyl chloride; water; potassium hydroxide; In tetrahydrofuran; methanol; carbon disulfide; 3.1: |Friedel-Crafts Acylation;

DOI:10.1021/ma302300g

upstream raw materials:

5-methoxyisophthalic acid

3,5-bis(4-methoxybenzoyl)anisole

5-Hydroxyisophthalic acid

4-methoxy-1,3-benzenedicarbonyl dichloride

Downstream raw materials:

3,5-bis[(4-methoxyphenyl)methyl]anisole

3,5-bis[(4-hydroxyphenyl)methyl]phenol

3,5-bis[(4-cyanatophenyl)methyl]phenylcyanate