5-METHOXYISOPHTHALIC ACID

Base Information

• Chemical Name: 5-METHOXYISOPHTHALIC ACID
• CAS No.: 46331-50-4
• Molecular Formula: C9H8O5
• Molecular Weight: 196.16
• Hs Code.: 29189900
• Mol file: 46331-50-4.mol

Synonyms:Isophthalicacid, 5-methoxy- (6CI,7CI);5-Methoxy-1,3-benzenedicarboxylic acid;5-Methoxyisophthalic acid;NSC 302547;

Chemical Property of 5-METHOXYISOPHTHALIC ACID

Chemical Property:

• Melting Point: 275-280 °C(lit.)
• Boiling Point: 440.8 °C at 760 mmHg
• PKA: 3.41±0.10(Predicted)
• Flash Point: 183.6 °C
• PSA: 83.83000
• Density: 1.416 g/cm³
• LogP: 1.09160
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: DMSO, Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Methoxyisophthalic Acid ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 5-Methoxyisophthalic Acid is a humic acid degradation product found in soil. 5-Methoxyisophthalic Acid is also used in the synthesis of mesophases formed by several homologs of achiral seven-ring bent-core compounds. 5-Methoxyisophthalic acid (MeO-H2ip) may be used to synthesize [bpp = 1,3-di(4-pyridyl)propane]:5-methoxy bis(4-benzyloxy)phenylisophthalate3,5-bis(4-fluorobenzoyl)phenol[Cd2(MeO-ip)2(bpp)2]n·nH2O[Ni(MeO-ip)(bpp)(H2O)]n·nH2O

Technology Process of 5-METHOXYISOPHTHALIC ACID

There total 15 articles about 5-METHOXYISOPHTHALIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

dimethyl 5-methoxyisophthalate (20319-44-2) → 5-methoxyisophthalic acid (46331-50-4)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; for 6h; Reflux;

DOI:10.1002/chem.201700848

Reference yield: 63.0%

dimethyl 5-methoxyisophthalate (20319-44-2) → 5-methoxyisophthalic acid (46331-50-4) + 5-methoxy-isophthalic acid monomethyl ester (71590-08-4)

Guidance literature:

With hydrogenchloride; potassium hydroxide; In water; for 24h; Inert atmosphere;

DOI:10.1021/jo301872n

Reference yield: 61.0%

3,5-dimethylmethoxybenzene (874-63-5) → 5-methoxyisophthalic acid (46331-50-4)

Guidance literature:

In sodium hydroxide;

DOI:10.1016/S0040-4039(00)96148-3

upstream raw materials:

3,5-dimethylmethoxybenzene

3-ethyl-5-methyl-anisole

dimethylsulfone

5-Hydroxyisophthalic acid

Downstream raw materials:

5-methoxy-1,3-cyclohexanedicarboxylic acid

5-methoxy-N,N'-dipropyl-isophthalamide

1-Methoxy-2-methyl-3,5-bis-trifluoromethyl-benzene

2-Methoxy-4,6-bis-trifluoromethyl-benzaldehyde

Refernces

• 1、 Wang, Zhaoxu,Luo, Xin,Zheng, Baishu,Huang, Lu,Hang, Cheng,Jiao, Yinchun,Cao, Xiyang,Zeng, Wenjiang,Yun, Ruirui. "Highly Selective Carbon Dioxide Capture and Cooperative Catalysis of a Water-Stable Acylamide-Functionalized Metal–Organic Framework". . p. 1309 - 1314. Retrieved 2018/04/02.
• 2、 McCormick, Laura J.,Morris, Samuel A.,Slawin, Alexandra M. Z.,Teat, Simon J.,Morris, Russell E.. "Coordination polymers of 5-substituted isophthalic acid". . p. 1123 - 1132. Retrieved 2016/02/18.