anti-((3R,4R,5E,7E)-2-(bromomethyl)-3,5,7,9,9-pentamethyl-1,5,7-trien-4-yloxy)(tert-butyl)diphenylsilane

Base Information

Chemical Name:anti-((3R,4R,5E,7E)-2-(bromomethyl)-3,5,7,9,9-pentamethyl-1,5,7-trien-4-yloxy)(tert-butyl)diphenylsilane
CAS No.:916461-46-6
Molecular Formula:C₃₂H₄₅BrOSi
Molecular Weight:553.698
Hs Code.:

Synonyms:anti-((3R,4R,5E,7E)-2-(bromomethyl)-3,5,7,9,9-pentamethyl-1,5,7-trien-4-yloxy)(tert-butyl)diphenylsilane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of anti-((3R,4R,5E,7E)-2-(bromomethyl)-3,5,7,9,9-pentamethyl-1,5,7-trien-4-yloxy)(tert-butyl)diphenylsilane

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Technology Process of anti-((3R,4R,5E,7E)-2-(bromomethyl)-3,5,7,9,9-pentamethyl-1,5,7-trien-4-yloxy)(tert-butyl)diphenylsilane

There total 5 articles about anti-((3R,4R,5E,7E)-2-(bromomethyl)-3,5,7,9,9-pentamethyl-1,5,7-trien-4-yloxy)(tert-butyl)diphenylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 916461-45-5
anti-(3R,4R,5E,7E)-4-(tert-butyldiphenylsilyloxy)-3,5,7,9,9-pentamethyl-2-methylenedeca-5,7-dien-1-ol

: 916461-46-6
anti-((3R,4R,5E,7E)-2-(bromomethyl)-3,5,7,9,9-pentamethyl-1,5,7-trien-4-yloxy)(tert-butyl)diphenylsilane

Guidance literature:: With N-Bromosuccinimide; triphenylphosphine; In dichloromethane; at -78 - 0 ℃; for 0.75h;
DOI:10.1039/b608193m

Reference yield:

: 916461-56-8
anti-(3R,4R,5E,7E)-3,5,7,9,9-pentamethyl-2-methylenedeca-5,7-diene-1,4-diol

: 916461-46-6
anti-((3R,4R,5E,7E)-2-(bromomethyl)-3,5,7,9,9-pentamethyl-1,5,7-trien-4-yloxy)(tert-butyl)diphenylsilane

Guidance literature:: Multi-step reaction with 4 steps

1: 79 percent / triethyl amine; 4-dimethylamino pyridine / CH₂Cl₂ / 3 h / 0 - 20 °C

2: 78 percent / AgNO₃ / dimethylformamide / 12 h / 0 - 20 °C

3: 94 percent / K₂CO₃ / methanol / 16 h / 20 °C

4: 74 percent / NBS; triphenylphosphine / CH₂Cl₂ / 0.75 h / -78 - 0 °C

With dmap; N-Bromosuccinimide; potassium carbonate; silver nitrate; triethylamine; triphenylphosphine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b608193m

Reference yield:

: anti-ethyl (3R,4R,5E,7E)-4-hydroxy-3,5,7,9,9-pentamethyl-2-methylenedeca-5,7-dienyl carbonate

: 916461-46-6
anti-((3R,4R,5E,7E)-2-(bromomethyl)-3,5,7,9,9-pentamethyl-1,5,7-trien-4-yloxy)(tert-butyl)diphenylsilane

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / AgNO₃ / dimethylformamide / 12 h / 0 - 20 °C

2: 94 percent / K₂CO₃ / methanol / 16 h / 20 °C

3: 74 percent / NBS; triphenylphosphine / CH₂Cl₂ / 0.75 h / -78 - 0 °C

With N-Bromosuccinimide; potassium carbonate; silver nitrate; triphenylphosphine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b608193m