Cbz(L-Phe)(α-aminoisobutyric acid₎₄OtBu

Base Information

• Chemical Name: Cbz(L-Phe)(α-aminoisobutyric acid₎₄OtBu
• CAS No.: 1187839-07-1
• Molecular Formula: C₃₇H₅₃N₅O₈
• Molecular Weight: 695.857
• Mol file: 1187839-07-1.mol

Synonyms:Cbz(L-Phe)(α-aminoisobutyric acid₎₄OtBu

Chemical Property of Cbz(L-Phe)(α-aminoisobutyric acid₎₄OtBu

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of Cbz(L-Phe)(α-aminoisobutyric acid₎₄OtBu

There total 3 articles about Cbz(L-Phe)(α-aminoisobutyric acid₎₄OtBu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

N-Cbz-L-Phe (1161-13-3) + H-(Aib)4-O-t-Bu (92844-95-6) → Cbz(L-Phe)(α-aminoisobutyric acid)4OtBu (1187839-07-1)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 8h;

DOI:10.1002/anie.200901892

Reference yield:

N-Cbz-L-Phe (1161-13-3) + H-Aib-OtBu (4512-32-7) → Cbz(L-Phe)(α-aminoisobutyric acid)4OtBu (1187839-07-1)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 72h;

DOI:10.1002/chem.201302648

Reference yield:

N3(α-aminoisobutyric acid)4OtBu (1187839-02-6) → Cbz(L-Phe)(α-aminoisobutyric acid)4OtBu (1187839-07-1)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / methanol

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / Inert atmosphere

With palladium on activated charcoal; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;

DOI:10.1039/c2cc00060a

upstream raw materials:

N-Cbz-L-Phe

H-(Aib)4-O-t-Bu

N₃(α-aminoisobutyric acid)₄OtBu

H-Aib-OtBu

Downstream raw materials:

Cbz(L-Phe)Aib₄OH

C₅₇H₈₆N₁₂O₁₃

C₅₈H₈₈N₁₂O₁₃

C₅₇H₈₆N₁₂O₁₄